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CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome

Overview of attention for article published in Scientific Reports, October 2017
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Title
CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome
Published in
Scientific Reports, October 2017
DOI 10.1038/s41598-017-11976-6
Pubmed ID
Authors

José Luis Torán, Susana Aguilar, Juan Antonio López, Carlos Torroja, Juan Antonio Quintana, Cesar Santiago, José Luis Abad, Patricia Gomes-Alves, Andrés Gonzalez, Juan Antonio Bernal, Luis Jesús Jiménez-Borreguero, Paula Marques Alves, Luis R-Borlado, Jesús Vázquez, Antonio Bernad

Abstract

Studies in recent years have established that the principal effects in cardiac cell therapy are associated with paracrine/autocrine factors. We combined several complementary techniques to define human cardiac progenitor cell (CPC) secretome constituted by 914 proteins/genes; 51% of these are associated with the exosomal compartment. To define the set of proteins specifically or highly differentially secreted by CPC, we compared human mesenchymal stem cells and dermal fibroblasts; the study defined a group of growth factors, cytokines and chemokines expressed at high to medium levels by CPC. Among them, IL-1, GROa (CXCL1), CXCL6 (GCP2) and IL-8 are examples whose expression was confirmed by most techniques used. ELISA showed that CXCL6 is significantly overexpressed in CPC conditioned medium (CM) (18- to 26-fold) and western blot confirmed expression of its receptors CXCR1 and CXCR2. Addition of anti-CXCL6 completely abolished migration in CPC-CM compared with anti-CXCR2, which promoted partial inhibition, and anti-CXCR1, which was inefficient. Anti-CXCL6 also significantly inhibited CPC CM angiogenic activity. In vivo evaluation also supported a relevant role for angiogenesis. Altogether, these results suggest a notable angiogenic potential in CPC-CM and identify CXCL6 as an important paracrine factor for CPC that signals mainly through CXCR2.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Ph. D. Student 8 15%
Student > Master 5 9%
Student > Doctoral Student 4 8%
Student > Bachelor 2 4%
Other 8 15%
Unknown 16 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 23%
Agricultural and Biological Sciences 4 8%
Medicine and Dentistry 4 8%
Nursing and Health Professions 3 6%
Materials Science 2 4%
Other 9 17%
Unknown 19 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2019.
All research outputs
#17,916,739
of 23,003,906 outputs
Outputs from Scientific Reports
#87,812
of 124,216 outputs
Outputs of similar age
#231,123
of 322,939 outputs
Outputs of similar age from Scientific Reports
#3,527
of 5,327 outputs
Altmetric has tracked 23,003,906 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 124,216 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,939 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,327 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.