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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
|
|---|---|
| Published in |
Nature Biomedical Engineering, October 2017
|
| DOI | 10.1038/s41551-017-0137-2 |
| Pubmed ID | |
| Authors |
Kunwoo Lee, Michael Conboy, Hyo Min Park, Fuguo Jiang, Hyun Jin Kim, Mark A. Dewitt, Vanessa A. Mackley, Kevin Chang, Anirudh Rao, Colin Skinner, Tamanna Shobha, Melod Mehdipour, Hui Liu, Wen-chin Huang, Freeman Lan, Nicolas L. Bray, Song Li, Jacob E. Corn, Kazunori Kataoka, Jennifer A. Doudna, Irina Conboy, Niren Murthy |
| Abstract |
CRISPR/Cas9-based therapeutics, especially those that can correct gene mutations via homology directed repair (HDR), have the potential to revolutionize the treatment of genetic diseases. However, HDR-based therapeutics are challenging to develop because they require simultaneous in vivo delivery of Cas9 protein, guide RNA and donor DNA. Here, we demonstrate that a delivery vehicle composed of gold nanoparticles conjugated to DNA and complexed with cationic endosomal disruptive polymers can deliver Cas9 ribonucleoprotein and donor DNA into a wide variety of cell types, and efficiently correct the DNA mutation that causes Duchenne muscular dystrophy in mice via local injection, with minimal off-target DNA damage. |
X Demographics
The data shown below were collected from the profiles of 234 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 84 | 36% |
| United Kingdom | 15 | 6% |
| France | 9 | 4% |
| Spain | 5 | 2% |
| Japan | 4 | 2% |
| Canada | 4 | 2% |
| Australia | 4 | 2% |
| Netherlands | 4 | 2% |
| India | 3 | 1% |
| Other | 24 | 10% |
| Unknown | 78 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 138 | 59% |
| Scientists | 76 | 32% |
| Science communicators (journalists, bloggers, editors) | 14 | 6% |
| Practitioners (doctors, other healthcare professionals) | 6 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 949 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 949 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 205 | 22% |
| Student > Bachelor | 146 | 15% |
| Researcher | 117 | 12% |
| Student > Master | 85 | 9% |
| Student > Doctoral Student | 44 | 5% |
| Other | 114 | 12% |
| Unknown | 238 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 273 | 29% |
| Agricultural and Biological Sciences | 110 | 12% |
| Chemistry | 65 | 7% |
| Engineering | 62 | 7% |
| Medicine and Dentistry | 34 | 4% |
| Other | 124 | 13% |
| Unknown | 281 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 568. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#42,565
of 25,765,370 outputs
Outputs from Nature Biomedical Engineering
#16
of 1,153 outputs
Outputs of similar age
#836
of 333,088 outputs
Outputs of similar age from Nature Biomedical Engineering
#1
of 32 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,153 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 79.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.