Title |
Emotional impact on the results of BRCA1 and BRCA2 genetic test: an observational retrospective study
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Published in |
Hereditary Cancer in Clinical Practice, October 2017
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DOI | 10.1186/s13053-017-0077-6 |
Pubmed ID | |
Authors |
Sara Mella, Barbara Muzzatti, Riccardo Dolcetti, Maria Antonietta Annunziata |
Abstract |
BRCA1 and BRCA2 mutations are associated with a higher risk of breast and ovarian tumors. This study evaluated the emotional states of women 1 month after having received the results of the genetic test and assessed eventual associations with the type of outcome, personal/familiar disease history and major socio-demographic variables. The study, an observational retrospective one, involved 91 women, evaluated 1 month after receiving their results. Patients were administered the Hospital Anxiety and Depression Scale, the Profile of Mood States and emotional Thermometers. Anxiety was significantly higher than depression (p < 0.001), and 21.3% and 21.3% of the sample were, respectively, possible and probable cases for anxiety, whereas 13.5% and 10.1% were possible and probable cases for depression. Within the six mood states, Confusion-Bewilderment (M = 48.5) was the lowest, whereas Fatigue-Inertia (M = 52.3) was the highest. Differences were recorded within the ten assessed emotions too. Being a proband/nonproband and being or not a cancer patient were associated with many tested variables. The psycho-emotional screening of women undertaking genetic counseling is relevant and should cover a large range of dimensions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 17% |
Spain | 1 | 8% |
Nigeria | 1 | 8% |
Venezuela, Bolivarian Republic of | 1 | 8% |
Unknown | 7 | 58% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 19% |
Student > Master | 6 | 12% |
Student > Doctoral Student | 4 | 8% |
Professor | 3 | 6% |
Researcher | 3 | 6% |
Other | 8 | 15% |
Unknown | 18 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Nursing and Health Professions | 4 | 8% |
Agricultural and Biological Sciences | 4 | 8% |
Psychology | 3 | 6% |
Other | 7 | 13% |
Unknown | 18 | 35% |