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Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene

Overview of attention for article published in Molecular Neurodegeneration, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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1 blog
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Citations

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63 Dimensions

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119 Mendeley
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Title
Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
Published in
Molecular Neurodegeneration, September 2014
DOI 10.1186/1750-1326-9-38
Pubmed ID
Authors

Marka van Blitterswijk, Bianca Mullen, Aleksandra Wojtas, Michael G Heckman, Nancy N Diehl, Matthew C Baker, Mariely DeJesus-Hernandez, Patricia H Brown, Melissa E Murray, Ging-Yuek R Hsiung, Heather Stewart, Anna M Karydas, Elizabeth Finger, Andrew Kertesz, Eileen H Bigio, Sandra Weintraub, Marsel Mesulam, Kimmo J Hatanpaa, Charles L White, Manuela Neumann, Michael J Strong, Thomas G Beach, Zbigniew K Wszolek, Carol Lippa, Richard Caselli, Leonard Petrucelli, Keith A Josephs, Joseph E Parisi, David S Knopman, Ronald C Petersen, Ian R Mackenzie, William W Seeley, Lea T Grinberg, Bruce L Miller, Kevin B Boylan, Neill R Graff-Radford, Bradley F Boeve, Dennis W Dickson, Rosa Rademakers

Abstract

Hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9ORF72) are causative for frontotemporal dementia (FTD) and motor neuron disease (MND). Substantial phenotypic heterogeneity has been described in patients with these expansions. We set out to identify genetic modifiers of disease risk, age at onset, and survival after onset that may contribute to this clinical variability.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Colombia 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Belgium 1 <1%
Philippines 1 <1%
Unknown 112 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 18%
Student > Ph. D. Student 20 17%
Student > Doctoral Student 11 9%
Student > Master 10 8%
Other 9 8%
Other 25 21%
Unknown 23 19%
Readers by discipline Count As %
Neuroscience 24 20%
Medicine and Dentistry 21 18%
Agricultural and Biological Sciences 21 18%
Biochemistry, Genetics and Molecular Biology 7 6%
Psychology 5 4%
Other 10 8%
Unknown 31 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2015.
All research outputs
#3,111,598
of 23,128,387 outputs
Outputs from Molecular Neurodegeneration
#436
of 858 outputs
Outputs of similar age
#35,449
of 251,497 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 13 outputs
Altmetric has tracked 23,128,387 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 858 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.