Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

https://t.co/v1te2SRssM "Therefore, meclizine may be considered as a novel therapeutic candidate for osteoclast-related diseases."

https://t.co/v1te2SRssM "In conclusion, our results indicated that meclizine inhibits osteoclastogenesis via regulation of several RANKL signaling pathways and PXR was involved in the processes."

https://t.co/v1te2SRssM "Meanwhile, meclizine reduced the expression of osteoclast-specific genes, including TRAP, MMP9, Cathepsin K and NFATc1." "On the other hand, meclizine decreased OVX-induced bone loss by repressing osteoclast activity."

https://t.co/v1te2SRssM "On the one hand, at the molecular level, meclizine attenuated RANKL-induced activation of c-Fos, NFATc1, nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPKs), including ERK and p38, but not JNK."