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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials
|
|---|---|
| Published in |
Journal of Experimental & Clinical Cancer Research, August 2017
|
| DOI | 10.1186/s13046-017-0578-1 |
| Pubmed ID | |
| Authors |
Andrew S. Gdowski, Amalendu Ranjan, Jamboor K. Vishwanatha |
| Abstract |
Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer. Bone metastasis represents a difficult to treat clinical scenario due to pain, increased fracture risk, decreased quality of life and diminished overall survival outcomes. Multiple types of cancer have the specific ability to home to the bone microenvironment and cause metastatic lesions. This osteotropism was first described by Stephen Paget nearly 100 years ago as the 'seed and soil' hypothesis. Once cancer cells arrive at the bone they encounter a variety of cells native to the bone microenvironment which contribute to the establishment of bone metastatic lesions. In the first part of this review, the 'seed and soil' hypothesis is revisited while emphasizing recent developments in understanding the impact of native bone microenvironment cells on the metastatic process. Next, approved therapies for treating bone metastasis at the systemic level as well as those that target the bone microenvironment are discussed and current National Comprehensive Cancer Network (NCCN) guidelines relating to treatment of bone metastases are summarized. Finally, all open interventional clinical trials for therapies relating to treatment of bone metastasis have been complied and categorized. Understanding the recent advancements in bone metastasis research is important for continued development of novel bone targeted therapies. The plethora of ongoing clinical trials will hopefully translate into improved treatments options for patients suffering from bone metastatic cancers. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 50% |
| United Kingdom | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 18% |
| Researcher | 16 | 10% |
| Student > Ph. D. Student | 15 | 9% |
| Student > Master | 14 | 8% |
| Student > Doctoral Student | 8 | 5% |
| Other | 24 | 15% |
| Unknown | 59 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 22% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Agricultural and Biological Sciences | 9 | 5% |
| Engineering | 8 | 5% |
| Nursing and Health Professions | 7 | 4% |
| Other | 26 | 16% |
| Unknown | 62 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2021.
All research outputs
#15,097,241
of 25,382,440 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#859
of 2,380 outputs
Outputs of similar age
#168,910
of 328,185 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#8
of 26 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,380 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,185 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.