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Overview of attention for article published in Arthritis Research & Therapy, January 2006
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)

Mentioned by

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3 tweeters

Citations

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111 Dimensions

Readers on

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109 Mendeley
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Title
Published in
Arthritis Research & Therapy, January 2006
DOI 10.1186/ar2029
Pubmed ID
Authors

Francesco Dell'Accio, Cosimo De Bari, Noha MF El Tawil, Francesca Barone, Thimios A Mitsiadis, John O'Dowd, Costantino Pitzalis

Abstract

Acute full thickness joint surface defects can undergo repair, which involves tissue patterning and endochondral bone formation. Molecular signals regulating this process may contribute to the repair outcome, chronic evolution and, eventually, the onset of osteoarthritis. We tested the hypothesis that mechanical injury modulates morphogenetic pathways in adult human articular cartilage explants. Adjacent articular cartilage explants were obtained from preserved areas of the femoral condyles of patients undergoing arthroplasty for osteoarthritis, or from a normal joint of a patient undergoing lower limb amputation. Paired explants were individually maintained in explant culture. From each pair, one explant was mechanically injured and the other left uninjured as a control. Cultures were terminated at different time points for histochemistry, immunohistochemistry and gene expression analysis by reverse transcription real time PCR. Bone morphogenetic protein 2 (BMP-2) mRNA was upregulated in the injured explants. We detected phosphorylation of SMAD-1 and SMAD-5, consistent with activation of the bone morphogenetic protein (BMP) pathway. FRZB-1 mRNA was downregulated in the injured explants, suggesting de-repression of WNT signaling. Accordingly, expression of the canonical WNT target genes Axin-2 and c-JUN was upregulated in the injured explants. Activation of the canonical WNT signaling pathway by LiCl treatment induced upregulation of COL2A1 and Aggrecan mRNA, suggesting an anabolic effect. Phosphorylation of SMAD-1/-5 and downregulation of FRZB were confirmed in vivo in a mouse model of joint surface injury. Taken together, these data show modulation of the BMP and WNT pathways following mechanical injury in vitro and in vivo, which may play a role in the reparative response of the joint surface. These pathways may, therefore, represent potential targets in protocols of biological joint surface defect repair.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Finland 1 <1%
India 1 <1%
Belgium 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 102 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 28%
Researcher 23 21%
Student > Bachelor 14 13%
Professor 8 7%
Student > Master 8 7%
Other 16 15%
Unknown 9 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 35%
Medicine and Dentistry 26 24%
Biochemistry, Genetics and Molecular Biology 19 17%
Engineering 6 6%
Neuroscience 2 2%
Other 7 6%
Unknown 11 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2017.
All research outputs
#6,749,112
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#1,167
of 1,983 outputs
Outputs of similar age
#115,959
of 271,082 outputs
Outputs of similar age from Arthritis Research & Therapy
#2
of 2 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,082 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.