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Alteration in methylation level at 11β-hydroxysteroid dehydrogenase type 2 gene promoter in infants born to preeclamptic women

Overview of attention for article published in BMC Genetics, September 2014
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Title
Alteration in methylation level at 11β-hydroxysteroid dehydrogenase type 2 gene promoter in infants born to preeclamptic women
Published in
BMC Genetics, September 2014
DOI 10.1186/s12863-014-0096-5
Pubmed ID
Authors

Wensheng Hu, Xiaoling Weng, Minyue Dong, Yun Liu, Wenjuan Li, Hefeng Huang

Abstract

BackgroundPreeclampsia reduces placental expression and activity of 11ß-hydroxysteroid dehydrogenase type 2 (HSD11B2), leading to an increase in fetal glucocordicoids. The latter has been proposed to be associated with low birth weight and high risk of metabolic diseases in later life of the offspring. This investigation aims to delineate the alteration in methylation levels at CpG sites of HSD11B2 promoter.ResultsMethylation levels of HSD9-2, HSD9-3, HSD23-2 and HSD23-3 and the mean methylation level were significantly lower in preeclampsia than in normal pregnancy (P¿=¿0.002, 0.031, 0.047 and 0.001, respectively and P¿<¿0.001 in mean). The mean methylation level was significantly correlated with preeclampsia after the adjustment of birth weight, maternal age, gestational age at delivery and fetal gender (r¿=¿0.325, P¿<¿0.001).ConclusionsPreeclampsia reduced methylation level at fetal HSD11B2 promoter. A positive correlation existed between HSD11B2 promoter methylation and preeclampsia. Our findings suggest that the methyaltion status of HSD11B2 promoter is a potentially accessible biomarker for preeclampsia. However, further studies are required to address the mechanisms of thehypomethylation at HSD11B2 promoter and the significance of the hypomethylation in the development of metabolic diseases of the fetals born to preeclamptic women.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 39%
Student > Doctoral Student 4 14%
Student > Bachelor 4 14%
Other 2 7%
Researcher 2 7%
Other 3 11%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 25%
Medicine and Dentistry 6 21%
Biochemistry, Genetics and Molecular Biology 4 14%
Immunology and Microbiology 1 4%
Nursing and Health Professions 1 4%
Other 5 18%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2014.
All research outputs
#10,076,382
of 16,392,950 outputs
Outputs from BMC Genetics
#480
of 1,015 outputs
Outputs of similar age
#105,932
of 212,646 outputs
Outputs of similar age from BMC Genetics
#1
of 1 outputs
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So far Altmetric has tracked 1,015 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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