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Clinical recovery from surgery correlates with single-cell immune signatures

Overview of attention for article published in Science Translational Medicine, September 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
15 news outlets
blogs
1 blog
twitter
56 tweeters
weibo
1 weibo user
facebook
2 Facebook pages
googleplus
2 Google+ users

Citations

dimensions_citation
190 Dimensions

Readers on

mendeley
324 Mendeley
citeulike
1 CiteULike
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Title
Clinical recovery from surgery correlates with single-cell immune signatures
Published in
Science Translational Medicine, September 2014
DOI 10.1126/scitranslmed.3009701
Pubmed ID
Authors

Brice Gaudillière, Gabriela K. Fragiadakis, Robert V. Bruggner, Monica Nicolau, Rachel Finck, Martha Tingle, Julian Silva, Edward A. Ganio, Christine G. Yeh, William J. Maloney, James I. Huddleston, Stuart B. Goodman, Mark M. Davis, Sean C. Bendall, Wendy J. Fantl, Martin S. Angst, Garry P. Nolan

Abstract

Delayed recovery from surgery causes personal suffering and substantial societal and economic costs. Whether immune mechanisms determine recovery after surgical trauma remains ill-defined. Single-cell mass cytometry was applied to serial whole-blood samples from 32 patients undergoing hip replacement to comprehensively characterize the phenotypic and functional immune response to surgical trauma. The simultaneous analysis of 14,000 phosphorylation events in precisely phenotyped immune cell subsets revealed uniform signaling responses among patients, demarcating a surgical immune signature. When regressed against clinical parameters of surgical recovery, including functional impairment and pain, strong correlations were found with STAT3 (signal transducer and activator of transcription), CREB (adenosine 3',5'-monophosphate response element-binding protein), and NF-κB (nuclear factor κB) signaling responses in subsets of CD14(+) monocytes (R = 0.7 to 0.8, false discovery rate <0.01). These sentinel results demonstrate the capacity of mass cytometry to survey the human immune system in a relevant clinical context. The mechanistically derived immune correlates point to diagnostic signatures, and potential therapeutic targets, that could postoperatively improve patient recovery.

Twitter Demographics

The data shown below were collected from the profiles of 56 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 324 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 2%
United Kingdom 2 <1%
Denmark 2 <1%
Mexico 1 <1%
Korea, Republic of 1 <1%
Israel 1 <1%
Belgium 1 <1%
Sweden 1 <1%
Switzerland 1 <1%
Other 0 0%
Unknown 306 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 89 27%
Student > Ph. D. Student 71 22%
Student > Master 27 8%
Other 22 7%
Professor 20 6%
Other 64 20%
Unknown 31 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 97 30%
Medicine and Dentistry 71 22%
Immunology and Microbiology 44 14%
Biochemistry, Genetics and Molecular Biology 29 9%
Engineering 7 2%
Other 31 10%
Unknown 45 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 151. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2019.
All research outputs
#130,407
of 15,838,541 outputs
Outputs from Science Translational Medicine
#438
of 4,254 outputs
Outputs of similar age
#1,800
of 211,674 outputs
Outputs of similar age from Science Translational Medicine
#8
of 134 outputs
Altmetric has tracked 15,838,541 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,254 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,674 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.