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Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease

Overview of attention for article published in Journal of Clinical Microbiology, September 2014
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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2 tweeters
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2 patents

Citations

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98 Dimensions

Readers on

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99 Mendeley
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Title
Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease
Published in
Journal of Clinical Microbiology, September 2014
DOI 10.1128/jcm.01967-14
Pubmed ID
Authors

M. Garcia-Nunez, L. Millares, X. Pomares, R. Ferrari, V. Perez-Brocal, M. Gallego, M. Espasa, A. Moya, E. Monso

Abstract

Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based techniques only identify a part of the bacteria in mucosal surfaces. The aim of the study was to determine changes in the bronchial microbiome of COPD associated with the severity of the disease. Bronchial microbiome of COPD patients was analyzed by 16S rRNA gene amplification and pyrosequencing in sputum samples obtained during stability. Seventeen COPD patients were studied (forced expiratory volume in the first second [FEV1%] median 35.0% [interquartile range (IQR) 31.5-52.0]), providing a mean of 4493 (SD 2598) sequences corresponding to 47 Operational Taxonomic Units (OTUs) (SD 17) at a 97% identity level. Patients were dichotomized according to their lung function as moderate-severe, when their FEV1% was over the median, and as advanced, when FEV1% values were lower. Most prevalent phyla in sputum were Proteobacteria (44%) and Firmicutes (16%), followed by Actinobacteria (13%). A greater microbial diversity was found in patients with moderate-severe disease, and alpha-diversity showed a statistically significant decrease in patients with advanced disease when assessed by Shannon (ρ=0.528, p=0.029, Spearman correlation coeficient) and Chao1 alpha diversity indexes (ρ=0.53, p=0.028, Spearman correlation coeficient). The higher severity that characterizes advanced COPD is paralleled by a decrease in the diversity of bronchial microbiome, with a loss of part of the resident flora, that is replaced by a more restricted microbiota that includes PPMs.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 2%
United Kingdom 1 1%
Korea, Republic of 1 1%
Spain 1 1%
United States 1 1%
Unknown 93 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 27%
Student > Ph. D. Student 17 17%
Student > Master 15 15%
Student > Doctoral Student 7 7%
Professor > Associate Professor 7 7%
Other 14 14%
Unknown 12 12%
Readers by discipline Count As %
Medicine and Dentistry 25 25%
Agricultural and Biological Sciences 24 24%
Biochemistry, Genetics and Molecular Biology 12 12%
Immunology and Microbiology 12 12%
Computer Science 2 2%
Other 12 12%
Unknown 12 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2018.
All research outputs
#3,987,528
of 14,803,679 outputs
Outputs from Journal of Clinical Microbiology
#3,375
of 10,324 outputs
Outputs of similar age
#51,776
of 210,225 outputs
Outputs of similar age from Journal of Clinical Microbiology
#24
of 121 outputs
Altmetric has tracked 14,803,679 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 10,324 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.