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Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease

Overview of attention for article published in Journal of Clinical Microbiology, September 2014
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Mentioned by

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2 tweeters

Citations

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73 Dimensions

Readers on

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72 Mendeley
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Title
Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease
Published in
Journal of Clinical Microbiology, September 2014
DOI 10.1128/jcm.01967-14
Pubmed ID
Authors

M. Garcia-Nunez, L. Millares, X. Pomares, R. Ferrari, V. Perez-Brocal, M. Gallego, M. Espasa, A. Moya, E. Monso

Abstract

Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based techniques only identify a part of the bacteria in mucosal surfaces. The aim of the study was to determine changes in the bronchial microbiome of COPD associated with the severity of the disease. Bronchial microbiome of COPD patients was analyzed by 16S rRNA gene amplification and pyrosequencing in sputum samples obtained during stability. Seventeen COPD patients were studied (forced expiratory volume in the first second [FEV1%] median 35.0% [interquartile range (IQR) 31.5-52.0]), providing a mean of 4493 (SD 2598) sequences corresponding to 47 Operational Taxonomic Units (OTUs) (SD 17) at a 97% identity level. Patients were dichotomized according to their lung function as moderate-severe, when their FEV1% was over the median, and as advanced, when FEV1% values were lower. Most prevalent phyla in sputum were Proteobacteria (44%) and Firmicutes (16%), followed by Actinobacteria (13%). A greater microbial diversity was found in patients with moderate-severe disease, and alpha-diversity showed a statistically significant decrease in patients with advanced disease when assessed by Shannon (ρ=0.528, p=0.029, Spearman correlation coeficient) and Chao1 alpha diversity indexes (ρ=0.53, p=0.028, Spearman correlation coeficient). The higher severity that characterizes advanced COPD is paralleled by a decrease in the diversity of bronchial microbiome, with a loss of part of the resident flora, that is replaced by a more restricted microbiota that includes PPMs.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 3%
United Kingdom 1 1%
United States 1 1%
Korea, Republic of 1 1%
Unknown 67 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 31%
Student > Ph. D. Student 15 21%
Student > Master 8 11%
Professor > Associate Professor 6 8%
Unspecified 5 7%
Other 16 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 31%
Medicine and Dentistry 22 31%
Unspecified 8 11%
Biochemistry, Genetics and Molecular Biology 5 7%
Immunology and Microbiology 5 7%
Other 10 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2014.
All research outputs
#7,754,771
of 12,360,337 outputs
Outputs from Journal of Clinical Microbiology
#5,360
of 7,013 outputs
Outputs of similar age
#109,710
of 215,115 outputs
Outputs of similar age from Journal of Clinical Microbiology
#79
of 147 outputs
Altmetric has tracked 12,360,337 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,013 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,115 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.