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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo
|
|---|---|
| Published in |
Stem Cell Research & Therapy, September 2014
|
| DOI | 10.1186/scrt500 |
| Pubmed ID | |
| Authors |
Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger |
| Abstract |
Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. Furthermore, the effects of ar-turmerone on neural stem cells (NSCs) remain to be investigated. We exposed primary fetal rat NSCs to various concentrations of ar-turmerone. Thereafter, cell proliferation and differentiation potential were assessed. In vivo, naïve rats were treated with a single intracerebroventricular (i.c.v.) injection of ar-turmerone. Proliferative activity of endogenous NSCs was assessed in vivo, by using noninvasive positron emission tomography (PET) imaging and the tracer [(18)F]-fluoro-L-thymidine ([(18)F]FLT), as well as ex vivo. In vitro, ar-turmerone increased dose-dependently the number of cultured NSCs, because of an increase in NSC proliferation (P < 0.01). Proliferation data were supported by qPCR-data for Ki-67 mRNA. In vitro as well as in vivo, ar-turmerone promoted neuronal differentiation of NSCs. In vivo, after i.c.v. injection of ar-turmerone, proliferating NSCs were mobilized from the subventricular zone (SVZ) and the hippocampus of adult rats, as demonstrated by both [(18)F]FLT-PET and histology (P < 0.05). Both in vitro and in vivo data suggest that ar-turmerone induces NSC proliferation. Ar-turmerone thus constitutes a promising candidate to support regeneration in neurologic disease. |
X Demographics
The data shown below were collected from the profiles of 74 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 24% |
| United Kingdom | 15 | 20% |
| Canada | 3 | 4% |
| Spain | 3 | 4% |
| Qatar | 1 | 1% |
| Argentina | 1 | 1% |
| New Zealand | 1 | 1% |
| Belgium | 1 | 1% |
| France | 1 | 1% |
| Other | 10 | 14% |
| Unknown | 20 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 57 | 77% |
| Practitioners (doctors, other healthcare professionals) | 8 | 11% |
| Scientists | 7 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| United States | 2 | 2% |
| Unknown | 116 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 18% |
| Researcher | 21 | 18% |
| Student > Ph. D. Student | 18 | 15% |
| Student > Master | 14 | 12% |
| Other | 7 | 6% |
| Other | 15 | 13% |
| Unknown | 23 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 9% |
| Medicine and Dentistry | 10 | 8% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Chemistry | 8 | 7% |
| Other | 28 | 23% |
| Unknown | 28 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 322. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2023.
All research outputs
#106,199
of 25,837,817 outputs
Outputs from Stem Cell Research & Therapy
#2
of 2,801 outputs
Outputs of similar age
#891
of 265,584 outputs
Outputs of similar age from Stem Cell Research & Therapy
#1
of 24 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,801 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.