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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Delivering a disease-modifying treatment for Huntington's disease
|
|---|---|
| Published in |
Drug Discovery Today, January 2015
|
| DOI | 10.1016/j.drudis.2014.09.011 |
| Pubmed ID | |
| Authors |
Bruno M.D.C. Godinho, Meenakshi Malhotra, Caitriona M. O’Driscoll, John F. Cryan |
| Abstract |
Huntington's disease (HD) is an incurable genetic neurodegenerative disorder that leads to motor and cognitive decline. It is caused by an expanded polyglutamine tract within the Huntingtin (HTT) gene, which translates into a toxic mutant HTT protein. Although no cure has yet been discovered, novel therapeutic strategies, such as RNA interference (RNAi), antisense oligonucleotides (ASO), ribozymes, DNA enzymes, and genome-editing approaches, aimed at silencing or repairing the mutant HTT gene hold great promise. Indeed, several preclinical studies have demonstrated the utility of such strategies to improve HD neuropathology and symptoms. In this review, we critically summarise the main advances and limitations of each gene-silencing technology as an effective therapeutic tool for the treatment of HD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Ireland | 2 | 40% |
| United Kingdom | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| Kazakhstan | 1 | <1% |
| Unknown | 145 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 31 | 21% |
| Student > Master | 29 | 19% |
| Researcher | 23 | 15% |
| Student > Ph. D. Student | 15 | 10% |
| Other | 7 | 5% |
| Other | 18 | 12% |
| Unknown | 27 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 27% |
| Biochemistry, Genetics and Molecular Biology | 30 | 20% |
| Medicine and Dentistry | 16 | 11% |
| Neuroscience | 15 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 15 | 10% |
| Unknown | 26 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2023.
All research outputs
#4,937,106
of 24,387,992 outputs
Outputs from Drug Discovery Today
#763
of 2,723 outputs
Outputs of similar age
#67,208
of 361,983 outputs
Outputs of similar age from Drug Discovery Today
#12
of 29 outputs
Altmetric has tracked 24,387,992 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,723 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.