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NMDA Receptors

Overview of attention for book
Cover of 'NMDA Receptors'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 NMDA Receptors in the Central Nervous System
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    Chapter 2 Quantification of NMDAR Subunit Genes Expression by qRT-PCR
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    Chapter 3 Genetic and Functional Analysis of GRIN2A in Tumor Samples
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    Chapter 4 Detection of NMDARs Antibodies in Encephalitis
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    Chapter 5 Magnetofection™ of NMDA Receptor Subunits GluN1 and GluN2A Expression Vectors in Non-Neuronal Host Cells
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    Chapter 6 Transfection in Primary Cultured Neuronal Cells
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    Chapter 7 Selective Cell-Surface Expression of Triheteromeric NMDA Receptors
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    Chapter 8 Functional Analysis of Recombinant Channels in Host Cells Using a Fast Agonist Application System
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    Chapter 9 GluN2B Subunit Labeling with Fluorescent Probes and High-Resolution Live Imaging
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    Chapter 10 Design of Light-Sensitive NMDARs by Genetically Encoded Photo-Cross-Linkers
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    Chapter 11 Gene Targeted Mice with Conditional Knock-In (-Out) of NMDAR Mutations
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    Chapter 12 Electrophysiological Investigation of NMDA Current Properties in Brain Slices
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    Chapter 13 Analysis of Functional NMDA Receptors in Astrocytes
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    Chapter 14 GluNs Detection and Functions in Microglial Cells
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    Chapter 15 NMDA Receptor Activity in Circulating Red Blood Cells: Methods of Detection
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    Chapter 16 NMDA Receptors as Voltage Sensors
  18. Altmetric Badge
    Chapter 17 Development of a Computational Approach/Model to Explore NMDA Receptors Functions
Attention for Chapter 12: Electrophysiological Investigation of NMDA Current Properties in Brain Slices
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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Chapter title
Electrophysiological Investigation of NMDA Current Properties in Brain Slices
Chapter number 12
Book title
NMDA Receptors
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-7321-7_12
Pubmed ID
28986876
Book ISBNs
978-1-4939-7320-0, 978-1-4939-7321-7
Authors

Alexandre Pons-Bennaceur, Natalia Lozovaya, Pons-Bennaceur, Alexandre, Lozovaya, Natalia

Abstract

Analysis of electrophysiological properties of NMDARs and NMDAR-mediated synaptic transmission in identified neurons and synapses in brain slices is a major step in understanding their function in normal and pathological neuronal brain networks. In many central synapses excitatory postsynaptic currents (EPSCs) are mediated by excitatory neurotransmitter glutamate that activates colocalized AMPAR and NMDAR generating a complex EPSC. Here, we describe the methods commonly used in brain slices to study the electrophysiological properties of NMDAR-mediated component of spontaneous or evoked EPSCs by extracellular stimulation or by stimulating synaptically connected neurons. This approach is based on whole-cell patch-clamp recordings, pharmacological tools, and the analysis of the difference in temporal parameters between the AMPA and NMDA receptors. It allows pinpointing of the basic functional properties of NMDARs that are specific to identified brain regions, neurons, and synapses of wild-type or genetically manipulated mice.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Professor 2 25%
Student > Bachelor 2 25%
Researcher 1 13%
Student > Doctoral Student 1 13%
Unknown 2 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 25%
Neuroscience 2 25%
Psychology 1 13%
Unknown 3 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2024.
All research outputs
#7,597,440
of 25,918,104 outputs
Outputs from Methods in molecular biology
#2,308
of 14,416 outputs
Outputs of similar age
#129,169
of 427,274 outputs
Outputs of similar age from Methods in molecular biology
#238
of 1,093 outputs
Altmetric has tracked 25,918,104 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 14,416 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 427,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1,093 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.

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