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Store-Operated Ca²⁺ Entry (SOCE) Pathways

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Cover of 'Store-Operated Ca²⁺ Entry (SOCE) Pathways'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction
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    Chapter 2 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
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    Chapter 3 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel
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    Chapter 4 The STIM-Orai Pathway: The Interactions Between STIM and Orai
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    Chapter 5 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry
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    Chapter 6 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
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    Chapter 7 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
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    Chapter 8 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
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    Chapter 9 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
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    Chapter 10 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex
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    Chapter 11 Introduction
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    Chapter 12 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
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    Chapter 13 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
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    Chapter 14 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria
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    Chapter 15 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry
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    Chapter 16 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
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    Chapter 17 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
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    Chapter 18 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
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    Chapter 19 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes
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    Chapter 20 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells
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    Chapter 21 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
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    Chapter 22 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
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    Chapter 23 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction
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    Chapter 24 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
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    Chapter 25 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology
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    Chapter 26 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
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    Chapter 27 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
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    Chapter 28 Neurological and Motor Disorders: TRPC in the Skeletal Muscle
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    Chapter 29 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation
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    Chapter 30 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease
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    Chapter 31 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion
Attention for Chapter 27: Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
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Chapter title
Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
Chapter number 27
Book title
Store-Operated Ca²⁺ Entry (SOCE) Pathways
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-57732-6_27
Pubmed ID
Book ISBNs
978-3-31-957731-9, 978-3-31-957732-6
Authors

Sunitha Bollimuntha, Biswaranjan Pani, Brij B. Singh

Abstract

Calcium (Ca(2+)) is a ubiquitous second messenger that performs significant physiological task such as neurosecretion, exocytosis, neuronal growth/differentiation, and the development and/or maintenance of neural circuits. An important regulatory aspect of neuronal Ca(2+) homeostasis is store-operated Ca(2+) entry (SOCE) which, in recent years, has gained much attention for influencing a variety of nerve cell responses. Essentially, activation of SOCE ensues following the activation of the plasma membrane (PM) store-operated Ca(2+) channels (SOCC) triggered by the depletion of endoplasmic reticulum (ER) Ca(2+) stores. In addition to the TRPC (transient receptor potential canonical) and the Orai family of ion channels, STIM (stromal interacting molecule) proteins have been baptized as key molecular regulators of SOCE. Functional significance of the TRPC channels in neurons has been elaborately studied; however, information on Orai and STIM components of SOCE, although seems imminent, is currently limited. Importantly, perturbations in SOCE have been implicated in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of SOCC in neurodegeneration would presumably unveil avenues for plausible therapeutic interventions. We thus review the role of SOCE-regulated neuronal Ca(2+) signaling in selecting neurodegenerative conditions.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 35%
Student > Master 2 10%
Researcher 2 10%
Student > Bachelor 2 10%
Student > Doctoral Student 1 5%
Other 4 20%
Unknown 2 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 20%
Neuroscience 4 20%
Agricultural and Biological Sciences 3 15%
Medicine and Dentistry 3 15%
Unspecified 1 5%
Other 2 10%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2017.
All research outputs
#11,094,068
of 13,978,928 outputs
Outputs from Advances in experimental medicine and biology
#1,921
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Outputs of similar age
#199,218
of 270,094 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
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