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Store-Operated Ca²⁺ Entry (SOCE) Pathways

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Cover of 'Store-Operated Ca²⁺ Entry (SOCE) Pathways'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction
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    Chapter 2 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
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    Chapter 3 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel
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    Chapter 4 The STIM-Orai Pathway: The Interactions Between STIM and Orai
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    Chapter 5 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry
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    Chapter 6 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
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    Chapter 7 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
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    Chapter 8 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
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    Chapter 9 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
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    Chapter 10 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex
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    Chapter 11 Introduction
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    Chapter 12 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
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    Chapter 13 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
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    Chapter 14 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria
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    Chapter 15 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry
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    Chapter 16 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
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    Chapter 17 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
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    Chapter 18 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
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    Chapter 19 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes
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    Chapter 20 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells
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    Chapter 21 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
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    Chapter 22 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
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    Chapter 23 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction
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    Chapter 24 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
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    Chapter 25 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology
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    Chapter 26 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
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    Chapter 27 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
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    Chapter 28 Neurological and Motor Disorders: TRPC in the Skeletal Muscle
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    Chapter 29 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation
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    Chapter 30 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease
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    Chapter 31 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion
Attention for Chapter 9: STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
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Chapter title
STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
Chapter number 9
Book title
Store-Operated Ca²⁺ Entry (SOCE) Pathways
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-57732-6_9
Pubmed ID
Book ISBNs
978-3-31-957731-9, 978-3-31-957732-6
Authors

Hwei Ling Ong, Indu S. Ambudkar

Abstract

Store-operated calcium entry (SOCE) is a ubiquitous Ca(2+) entry pathway that is activated in response to depletion of ER-Ca(2+) stores and critically controls the regulation of physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1-7), which are activated by stimuli leading to PIP2 hydrolysis, were first identified as molecular components of SOCE channels. While TRPC1 was associated with SOCE and regulation of function in several cell types, none of the TRPC members displayed I CRAC, the store-operated current identified in lymphocytes and mast cells. Intensive search finally led to the identification of Orai1 and STIM1 as the primary components of the CRAC channel. Orai1 was established as the pore-forming channel protein and STIM1 as the ER-Ca(2+) sensor protein involved in activation of Orai1. STIM1 also activates TRPC1 via a distinct domain in its C-terminus. However, TRPC1 function depends on Orai1-mediated Ca(2+) entry, which triggers recruitment of TRPC1 into the plasma membrane where it is activated by STIM1. TRPC1 and Orai1 form distinct store-operated Ca(2+) channels that regulate specific cellular functions. It is now clearly established that regulation of TRPC1 trafficking can change plasma membrane levels of the channel, the phenotype of the store-operated Ca(2+) current, as well as pattern of SOCE-mediated [Ca(2+)]i signals. Thus, TRPC1 is activated downstream of Orai1 and modifies the initial [Ca(2+)]i signal generated by Orai1. This review will highlight current concepts of the activation and regulation of TRPC1 channels and its impact on cell function.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Professor > Associate Professor 6 15%
Student > Master 5 13%
Student > Bachelor 4 10%
Student > Ph. D. Student 4 10%
Other 5 13%
Unknown 8 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 31%
Medicine and Dentistry 5 13%
Agricultural and Biological Sciences 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 5%
Unknown 12 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2017.
All research outputs
#8,764,591
of 13,978,928 outputs
Outputs from Advances in experimental medicine and biology
#1,448
of 3,339 outputs
Outputs of similar age
#157,248
of 270,094 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
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So far Altmetric has tracked 3,339 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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