Chapter title |
STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
|
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Chapter number | 8 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Dora Bodnar, Woo Young Chung, Dongki Yang, Jeong Hee Hong, Archana Jha, Shmuel Muallem |
Abstract |
Ca(2+) influx by plasma membrane Ca(2+) channels is the crucial component of the receptor-evoked Ca(2+) signal. The two main Ca(2+) influx channels of non-excitable cells are the Orai and TRPC families of Ca(2+) channels. These channels are activated in response to cell stimulation and Ca(2+) release from the endoplasmic reticulum (ER). The protein that conveys the Ca(2+) content of the ER to the plasma membrane is the ER Ca(2+) sensor STIM1. STIM1 activates the Orai channels and is obligatory for channel opening. TRPC channels can function in two modes, as STIM1-dependent and STIM1-independent. When activated by STIM1, both channel types function at the ER/PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca(2+)-dependent physiological functions that are not shared with the Orai channels. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 44% |
Student > Ph. D. Student | 3 | 19% |
Student > Master | 2 | 13% |
Student > Bachelor | 1 | 6% |
Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 50% |
Agricultural and Biological Sciences | 4 | 25% |
Immunology and Microbiology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Unknown | 1 | 6% |