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Store-Operated Ca²⁺ Entry (SOCE) Pathways

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Cover of 'Store-Operated Ca²⁺ Entry (SOCE) Pathways'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction
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    Chapter 2 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
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    Chapter 3 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel
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    Chapter 4 The STIM-Orai Pathway: The Interactions Between STIM and Orai
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    Chapter 5 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry
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    Chapter 6 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
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    Chapter 7 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
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    Chapter 8 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
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    Chapter 9 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
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    Chapter 10 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex
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    Chapter 11 Introduction
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    Chapter 12 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
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    Chapter 13 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
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    Chapter 14 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria
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    Chapter 15 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry
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    Chapter 16 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
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    Chapter 17 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
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    Chapter 18 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
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    Chapter 19 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes
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    Chapter 20 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells
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    Chapter 21 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
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    Chapter 22 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
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    Chapter 23 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction
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    Chapter 24 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
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    Chapter 25 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology
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    Chapter 26 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
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    Chapter 27 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
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    Chapter 28 Neurological and Motor Disorders: TRPC in the Skeletal Muscle
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    Chapter 29 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation
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    Chapter 30 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease
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    Chapter 31 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion
Attention for Chapter 22: Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
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Chapter title
Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
Chapter number 22
Book title
Store-Operated Ca²⁺ Entry (SOCE) Pathways
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-57732-6_22
Pubmed ID
Book ISBNs
978-3-31-957731-9, 978-3-31-957732-6
Authors

Jyoti Tanwar, Mohamed Trebak, Rajender K. Motiani

Abstract

Store-operated Ca(2+) entry (SOCE) mediated by STIM and Orai proteins is a highly regulated and ubiquitous signaling pathway that plays an important role in various cellular and physiological functions. Endoplasmic reticulum (ER) serves as the major site for intracellular Ca(2+) storage. Stromal Interaction Molecule 1/2 (STIM1/2) sense decrease in ER Ca(2+) levels and transmits the message to plasma membrane Ca(2+) channels constituted by Orai family members (Orai1/2/3) resulting in Ca(2+) influx into the cells. This increase in cytosolic Ca(2+) in turn activates a variety of signaling cascades to regulate a plethora of cellular functions. Evidence from the literature suggests that SOCE dysregulation is associated with several pathophysiologies, including vascular disorders. Interestingly, recent studies have suggested that STIM proteins may also regulate vascular functions independent of their contribution to SOCE. In this updated book chapter, we will focus on the physiological role of STIM and Orai proteins in the vasculature (endothelial cells and vascular smooth muscle cells). We will further retrospect the literature implicating a critical role for these proteins in vascular disease.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Professor 6 43%
Professor > Associate Professor 2 14%
Student > Ph. D. Student 2 14%
Other 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 29%
Agricultural and Biological Sciences 3 21%
Medicine and Dentistry 2 14%
Nursing and Health Professions 1 7%
Computer Science 1 7%
Other 1 7%
Unknown 2 14%