Chapter title |
Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
|
---|---|
Chapter number | 18 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_18 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Lothar A. Blatter |
Abstract |
Many cellular functions of the vascular endothelium are regulated by fine-tuned global and local, microdomain-confined changes of cytosolic free Ca(2+) ([Ca(2+)]i). Vasoactive agonist-induced stimulation of vascular endothelial cells (VECs) typically induces Ca(2+) release through IP3 receptor Ca(2+) release channels embedded in the membrane of the endoplasmic reticulum (ER) Ca(2+) store, followed by Ca(2+) entry from the extracellular space elicited by Ca(2+) store depletion and referred to as capacitative or store-operated Ca(2+) entry (SOCE). In vascular endothelial cells, SOCE is graded with the degree of store depletion and controlled locally in the subcellular microdomain where depletion occurs. SOCE provides distinct Ca(2+) signals that selectively control specific endothelial functions: in calf pulmonary artery endothelial cells, the SOCE Ca(2+) signal drives nitric oxide (an endothelium-derived relaxing factor of the vascular smooth muscle) production and controls activation and nuclear translocation of the transcription factor NFAT. Both cellular events are not affected by Ca(2+) signals of comparable magnitude arising directly from Ca(2+) release from intracellular stores, clearly indicating that SOCE regulates specific Ca(2+)-dependent cellular tasks by a unique and exclusive mechanism. This review discusses the mechanisms of intracellular Ca(2+) regulation in vascular endothelial cells and the role of store-operated Ca(2+) entry for endothelium-dependent smooth muscle relaxation and nitric oxide signaling, endothelial oxidative stress response, and excitation-transcription coupling in the vascular endothelium. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Unspecified | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Professor | 1 | 8% |
Other | 2 | 15% |
Unknown | 4 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 31% |
Agricultural and Biological Sciences | 2 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Unspecified | 1 | 8% |
Nursing and Health Professions | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |