Chapter title |
The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
|
---|---|
Chapter number | 2 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Jinhui Zhu, Qingping Feng, Peter B. Stathopulos |
Abstract |
Considerable progress has been made elucidating the molecular mechanisms of calcium (Ca(2+)) sensing by stromal interaction molecules (STIMs) and the basis for Orai channel activity. This chapter focuses on the available high-resolution structural details of STIM and Orai proteins with respect to the regulation of store-operated Ca(2+) entry (SOCE). Solution structures of the Ca(2+)-sensing domains of STIM1 and STIM2 are reviewed in detail, crystal structures of cytosolic coiled-coil STIM fragments are discussed, and an overview of the closed Drosophila melanogaster Orai hexameric structure is provided. Additionally, we highlight structures of human Orai1 N-terminal and C-terminal domains in complex with calmodulin and human STIM1, respectively. Ultimately, the accessible structural data are discussed in terms of potential mechanisms of action and cohesiveness with functional observations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 13% |
Student > Master | 2 | 13% |
Professor | 2 | 13% |
Other | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Other | 1 | 6% |
Unknown | 7 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 25% |
Agricultural and Biological Sciences | 3 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Chemistry | 1 | 6% |
Unknown | 7 | 44% |