Chapter title |
Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation
|
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Chapter number | 29 |
Book title |
Store-Operated Ca²⁺ Entry (SOCE) Pathways
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-57732-6_29 |
Pubmed ID | |
Book ISBNs |
978-3-31-957731-9, 978-3-31-957732-6
|
Authors |
Zoltan Machaty, Chunmin Wang, Kiho Lee, Lu Zhang |
Abstract |
At the time of fertilization, the sperm activates the egg and induces embryonic development by triggering an elevation in the egg's intracellular free Ca(2+) concentration. In mammals the initial Ca(2+) rise is followed by a series of repetitive Ca(2+) transients (known as oscillations) that last for several hours. Although the source of Ca(2+) during the signaling process is primarily the egg's smooth endoplasmic reticulum, the oscillations stop in the absence of extracellular Ca(2+) indicating that a Ca(2+) influx across the plasma membrane is essential to sustain them. Depletion of the intracellular stores using specific inhibitors generates a Ca(2+) entry across the plasma membrane of eggs of various species, and a continuous influx of Ca(2+) has been linked to the sperm-induced Ca(2+) oscillations in the mouse; these data indicate that store-operated Ca(2+) entry (SOCE) operates in eggs and may be the mechanism that maintains the long-lasting Ca(2+) signal at fertilization. Recent findings suggest that the signaling proteins STIM1 and Orai1 are present in eggs; they are responsible for mediating SOCE, and their functions are essential for proper Ca(2+) signaling at fertilization to support normal embryo development. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 2 | 25% |
Student > Master | 2 | 25% |
Professor > Associate Professor | 1 | 13% |
Unknown | 3 | 38% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 3 | 38% |
Biochemistry, Genetics and Molecular Biology | 2 | 25% |
Unknown | 3 | 38% |