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Store-Operated Ca²⁺ Entry (SOCE) Pathways

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Cover of 'Store-Operated Ca²⁺ Entry (SOCE) Pathways'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction
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    Chapter 2 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
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    Chapter 3 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel
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    Chapter 4 The STIM-Orai Pathway: The Interactions Between STIM and Orai
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    Chapter 5 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry
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    Chapter 6 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
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    Chapter 7 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
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    Chapter 8 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes
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    Chapter 9 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function
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    Chapter 10 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex
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    Chapter 11 Introduction
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    Chapter 12 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE
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    Chapter 13 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores
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    Chapter 14 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria
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    Chapter 15 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry
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    Chapter 16 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry
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    Chapter 17 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling
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    Chapter 18 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells
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    Chapter 19 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes
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    Chapter 20 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells
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    Chapter 21 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
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    Chapter 22 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders
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    Chapter 23 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction
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    Chapter 24 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
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    Chapter 25 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology
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    Chapter 26 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology
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    Chapter 27 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
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    Chapter 28 Neurological and Motor Disorders: TRPC in the Skeletal Muscle
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    Chapter 29 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation
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    Chapter 30 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease
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    Chapter 31 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion
Attention for Chapter 7: The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
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Chapter title
The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels
Chapter number 7
Book title
Store-Operated Ca²⁺ Entry (SOCE) Pathways
Published in
Advances in experimental medicine and biology, January 2017
DOI 10.1007/978-3-319-57732-6_7
Pubmed ID
Book ISBNs
978-3-31-957731-9, 978-3-31-957732-6
Authors

Guolin Ma, Shufan Wen, Yun Huang, Yubin Zhou

Abstract

Ca(2+) signals regulate a plethora of cellular functions that include muscle contraction, heart beating, hormone secretion, lymphocyte activation, gene expression, and metabolism. To study the impact of Ca(2+) signals on biological processes, pharmacological tools and caged compounds have been commonly applied to induce fluctuations of intracellular Ca(2+) concentrations. These conventional approaches, nonetheless, lack rapid reversibility and high spatiotemporal resolution. To overcome these disadvantages, we and others have devised a series of photoactivatable genetically encoded Ca(2+) actuators (GECAs) by installing light sensitivities into a bona fide highly selective Ca(2+) channel, the Ca(2+) release-activated Ca(2+) (CRAC) channel. Store-operated CRAC channel serves as a major route for Ca(2+) entry in many cell types. These GECAs enable remote and precise manipulation of Ca(2+) signaling in both excitable and non-excitable cells. When combined with nanotechnology, it becomes feasible to wirelessly photo-modulate Ca(2+)-dependent activities in vivo. In this chapter, we briefly review most recent advances in engineering CRAC channels to achieve optical control over Ca(2+) signaling, outline their design principles and kinetic features, and present exemplary applications of GECAs engineered from CRAC channels.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Student > Ph. D. Student 2 22%
Student > Master 1 11%
Professor 1 11%
Professor > Associate Professor 1 11%
Other 0 0%
Unknown 1 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 56%
Agricultural and Biological Sciences 1 11%
Immunology and Microbiology 1 11%
Neuroscience 1 11%
Unknown 1 11%