Chapter 1 Introduction

Chapter 2 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex

Chapter 3 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel

Chapter 4 The STIM-Orai Pathway: The Interactions Between STIM and Orai

Chapter 5 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry

Chapter 6 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications

Chapter 7 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels

Chapter 8 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes

Chapter 9 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function

Chapter 10 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex

Chapter 11 Introduction

Chapter 12 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE

Chapter 13 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores

Chapter 14 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria

Chapter 15 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry

Chapter 16 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry

Chapter 17 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling

Chapter 18 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells

Chapter 19 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes

Chapter 20 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells

Chapter 21 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes

Chapter 22 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders

Chapter 23 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction

Chapter 24 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention

Chapter 25 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology

Chapter 26 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology

Chapter 27 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function

Chapter 28 Neurological and Motor Disorders: TRPC in the Skeletal Muscle

Chapter 29 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation

Chapter 30 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease

Chapter 31 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion