Title |
Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial
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Published in |
Arthritis Research & Therapy, January 2014
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DOI | 10.1186/ar4446 |
Pubmed ID | |
Authors |
Muneaki Ishijima, Toshitaka Nakamura, Katsuji Shimizu, Kunihiko Hayashi, Hiraku Kikuchi, Satoshi Soen, Go Omori, Toshihiko Yamashita, Yuji Uchio, Junji Chiba, Yuki Ideno, Mitsuaki Kubota, Hisashi Kurosawa, Kazuo Kaneko, for the Research Group of Cartilage Metabolism |
Abstract |
While many of the commonly used conservative treatments for knee osteoarthritis (OA) have been recognized to be effective, there is still insufficient evidence available. Among the pharmacological treatments for knee OA, oral non-steroidal anti-inflammatory drugs (NSAIDs) act rapidly and are recommended for the management of OA. However, frequent and serious adverse effects of NSAIDs have been recognized. Intra-articular injections of hyaluronic acid (IA-HA) for the treatment of knee OA have been shown to reduce pain and improve joint function. However, there has been no qualified direct comparison study of the efficacy and safety between IA-HA and NSAIDs for patients with knee OA. The aim of this study was to clarify the efficacy and safety of early-phase IA-HA in comparison to those of NSAIDs for patients with knee OA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 165 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 29 | 17% |
Other | 19 | 11% |
Student > Bachelor | 19 | 11% |
Researcher | 14 | 8% |
Student > Doctoral Student | 11 | 7% |
Other | 32 | 19% |
Unknown | 43 | 26% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 11 | 7% |
Agricultural and Biological Sciences | 7 | 4% |
Neuroscience | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 14 | 8% |
Unknown | 50 | 30% |