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DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer

Overview of attention for article published in Biochemical & Biophysical Research Communications, December 2017
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Title
DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer
Published in
Biochemical & Biophysical Research Communications, December 2017
DOI 10.1016/j.bbrc.2017.10.015
Pubmed ID
Authors

Hayne Song, Jinhoi Song, Yeon Jeong Kim, Hyeon Hee Jeong, Hye Jin Min, Sang Seok Koh

Abstract

Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. However, underlying molecular mechanism of PAUF functioning in pancreatic cancer are not fully understood yet. The objective of this study was to evaluate the potential of demilune cell and parotid protein 1 (DCPP1) as a putative mouse ortholog of human PAUF by sequence alignment and functional studies. Overexpression of mouse DCPP1 in Chinese hamster ovary (CHO) cells or pancreatic cancer cells increased cell proliferation, migration, invasion, and adhesion ability in vitro. Treatment of human pancreatic cancer cells with recombinant mouse DCPP1 elevated cell growth, motility, invasiveness, and adhesiveness. Mouse DCPP1 exerted its function on pancreatic cancer cells by activating intracellular signaling pathways involved in aggressive cancer phenotype of human pancreatic cancer cells. Moreover, subcutaneous injection of mice with DCPP1-overexpressing CHO cells increased tumor sizes. Taken together, we conclude that mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 38%
Student > Master 3 38%
Other 1 13%
Researcher 1 13%
Readers by discipline Count As %
Medicine and Dentistry 6 75%
Biochemistry, Genetics and Molecular Biology 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2017.
All research outputs
#9,749,150
of 12,197,951 outputs
Outputs from Biochemical & Biophysical Research Communications
#17,511
of 20,504 outputs
Outputs of similar age
#199,480
of 273,634 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#125
of 356 outputs
Altmetric has tracked 12,197,951 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,504 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,634 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 356 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.