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RACK1 promotes the proliferation of THP1 acute myeloid leukemia cells

Overview of attention for article published in Molecular and Cellular Biochemistry, September 2013
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Title
RACK1 promotes the proliferation of THP1 acute myeloid leukemia cells
Published in
Molecular and Cellular Biochemistry, September 2013
DOI 10.1007/s11010-013-1798-0
Pubmed ID
Authors

Dalin Zhang, Qingyang Wang, Ting Zhu, Junxia Cao, Xueying Zhang, Jing Wang, Xiaoqian Wang, Yan Li, Beifen Shen, Jiyan Zhang

Abstract

The receptor for activated C kinase 1 (RACK1), an adaptor protein implicated in the regulation of multiple signaling pathways, has been reported to contribute to the survival of leukemic progenitor cells by enhancing the activity of glycogen synthase kinase 3β (GSK3β). However, it remains unknown whether RACK1 also contributes to the oncogenic growth of acute myeloid leukemia (AML) cells. Here, we report that transient or stable silencing of endogenous RACK1 expression by RACK1 short hairpin RNAs (shRNAs) led to impaired proliferation of THP1 AML cells without inducing terminal differentiation. Further exploration revealed that RACK1 loss-of-function resulted in reduced GSK3β activity. GSK3β shRNA treatment showed similar effects to RACK1 loss-of-function. Our data collectively suggest that RACK1 contributes to THP1 cell proliferation through, at least partially, enhancing GSK3β activity. Thus, targeting RACK1 may have some important therapeutic implications in the treatment of AML.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Professor 2 18%
Researcher 2 18%
Student > Master 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Other 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 27%
Agricultural and Biological Sciences 2 18%
Medicine and Dentistry 2 18%
Chemistry 2 18%
Unspecified 1 9%
Other 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2014.
All research outputs
#10,923,073
of 12,325,396 outputs
Outputs from Molecular and Cellular Biochemistry
#1,222
of 1,550 outputs
Outputs of similar age
#179,703
of 220,816 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#11
of 35 outputs
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So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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