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Effects of propofol on damage of rat intestinal epithelial cells induced by heat stress and lipopolysaccharides

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, June 2013
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Title
Effects of propofol on damage of rat intestinal epithelial cells induced by heat stress and lipopolysaccharides
Published in
Brazilian Journal of Medical and Biological Research, June 2013
DOI 10.1590/1414-431x20132785
Pubmed ID
Authors

J. Tang, Y. Jiang, Y. Tang, B. Chen, X. Sun, L. Su, Z. Liu

Abstract

Gut-derived endotoxin and pathogenic bacteria have been proposed as important causative factors of morbidity and death during heat stroke. However, it is still unclear what kind of damage is induced by heat stress. In this study, the rat intestinal epithelial cell line (IEC-6) was treated with heat stress or a combination of heat stress and lipopolysaccharide (LPS). In addition, propofol, which plays an important role in anti-inflammation and organ protection, was applied to study its effects on cellular viability and apoptosis. Heat stress, LPS, or heat stress combined with LPS stimulation can all cause intestinal epithelial cell damage, including early apoptosis and subsequent necrosis. However, propofol can alleviate injuries caused by heat stress, LPS, or the combination of heat stress and LPS. Interestingly, propofol can only mitigate LPS-induced intestinal epithelial cell apoptosis, and has no protective role in heat-stress-induced apoptosis. This study developed a model that can mimic the intestinal heat stress environment. It demonstrates the effects on intestinal epithelial cell damage, and indicated that propofol could be used as a therapeutic drug for the treatment of heat-stress-induced intestinal injuries.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Ph. D. Student 3 11%
Student > Bachelor 3 11%
Student > Master 3 11%
Student > Postgraduate 2 7%
Other 5 18%
Unknown 6 21%
Readers by discipline Count As %
Medicine and Dentistry 8 29%
Pharmacology, Toxicology and Pharmaceutical Science 3 11%
Nursing and Health Professions 2 7%
Agricultural and Biological Sciences 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Other 4 14%
Unknown 7 25%