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Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

Overview of attention for article published in Scientific Reports, October 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 141,863)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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294 news outlets
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24 blogs
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483 X users
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8 patents
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42 Facebook pages
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24 Wikipedia pages
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13 Google+ users
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9 Redditors
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7 YouTube creators

Citations

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357 Dimensions

Readers on

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1414 Mendeley
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1 CiteULike
Title
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Published in
Scientific Reports, October 2017
DOI 10.1038/s41598-017-13282-7
Pubmed ID
Authors

Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran, David J Nutt

Abstract

Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC. These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other 'psychedelics' yet were related to clinical outcomes. A 'reset' therapeutic mechanism is proposed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 483 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,414 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1414 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 317 22%
Student > Master 184 13%
Researcher 140 10%
Student > Ph. D. Student 116 8%
Other 71 5%
Other 157 11%
Unknown 429 30%
Readers by discipline Count As %
Neuroscience 213 15%
Psychology 212 15%
Medicine and Dentistry 166 12%
Biochemistry, Genetics and Molecular Biology 86 6%
Agricultural and Biological Sciences 69 5%
Other 197 14%
Unknown 471 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2797. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2024.
All research outputs
#2,527
of 25,582,611 outputs
Outputs from Scientific Reports
#31
of 141,863 outputs
Outputs of similar age
#29
of 336,259 outputs
Outputs of similar age from Scientific Reports
#3
of 5,129 outputs
Altmetric has tracked 25,582,611 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 141,863 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 5,129 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.