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Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

Overview of attention for article published in Scientific Reports, October 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 103,150)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
271 news outlets
blogs
21 blogs
twitter
535 tweeters
patent
3 patents
facebook
42 Facebook pages
wikipedia
15 Wikipedia pages
googleplus
13 Google+ users
reddit
9 Redditors
video
4 video uploaders

Citations

dimensions_citation
162 Dimensions

Readers on

mendeley
968 Mendeley
citeulike
1 CiteULike
Title
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Published in
Scientific Reports, October 2017
DOI 10.1038/s41598-017-13282-7
Pubmed ID
Authors

Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran, David J Nutt

Abstract

Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC. These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other 'psychedelics' yet were related to clinical outcomes. A 'reset' therapeutic mechanism is proposed.

Twitter Demographics

The data shown below were collected from the profiles of 535 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 968 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 968 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 255 26%
Student > Master 162 17%
Researcher 115 12%
Student > Ph. D. Student 99 10%
Other 51 5%
Other 106 11%
Unknown 180 19%
Readers by discipline Count As %
Psychology 177 18%
Neuroscience 170 18%
Medicine and Dentistry 128 13%
Biochemistry, Genetics and Molecular Biology 67 7%
Agricultural and Biological Sciences 63 7%
Other 144 15%
Unknown 219 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2665. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2021.
All research outputs
#1,648
of 19,196,842 outputs
Outputs from Scientific Reports
#20
of 103,150 outputs
Outputs of similar age
#22
of 292,869 outputs
Outputs of similar age from Scientific Reports
#1
of 130 outputs
Altmetric has tracked 19,196,842 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 103,150 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,869 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.