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Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?

Overview of attention for article published in Cancer & Metabolism, October 2014
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  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page

Readers on

mendeley
72 Mendeley
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Title
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
Published in
Cancer & Metabolism, October 2014
DOI 10.1186/2049-3002-2-16
Pubmed ID
Abstract

In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that promote tumorigenesis and how these pathways can be pharmacologically manipulated by conventional and targeted therapies. Despite not having complete knowledge of the mechanisms that cause cancer, the signaling networks responsible for cancer are becoming clearer, and this information is serving as a solid foundation for the development of rationally designed therapies. One goal of chemotherapy is to induce cancer cell death through the mitochondrial pathway of apoptosis. Within this review, we present the pathways that govern the cellular decision to undergo apoptosis as three distinct, yet connected puzzle pieces: (1) How do oncogene and tumor suppressor pathways regulate apoptosis upstream of mitochondria? (2) How does the B-cell lymphoma 2 (BCL-2) family influence tumorigenesis and chemotherapeutic responses? (3) How is post-mitochondrial outer membrane permeabilization (MOMP) regulation of cell death relevant in cancer? When these pieces are united, it is possible to appreciate how cancer signaling directly impacts upon the fundamental cellular mechanisms of apoptosis and potentially reveals novel pharmacological targets within these pathways that may enhance chemotherapeutic success.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Spain 1 1%
Kenya 1 1%
Unknown 68 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 29%
Student > Master 14 19%
Student > Bachelor 9 13%
Researcher 9 13%
Student > Doctoral Student 3 4%
Other 9 13%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 32%
Biochemistry, Genetics and Molecular Biology 23 32%
Medicine and Dentistry 6 8%
Chemistry 6 8%
Computer Science 1 1%
Other 5 7%
Unknown 8 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2015.
All research outputs
#2,183,797
of 6,230,816 outputs
Outputs from Cancer & Metabolism
#25
of 67 outputs
Outputs of similar age
#50,662
of 150,370 outputs
Outputs of similar age from Cancer & Metabolism
#3
of 8 outputs
Altmetric has tracked 6,230,816 research outputs across all sources so far. This one has received more attention than most of these and is in the 64th percentile.
So far Altmetric has tracked 67 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 150,370 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.