Title |
Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression
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Published in |
Biology of Mood & Anxiety Disorders, October 2014
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DOI | 10.1186/2045-5380-4-9 |
Pubmed ID | |
Authors |
Stephanie M Gorka, Brady D Nelson, K Luan Phan, Stewart A Shankman |
Abstract |
Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable aversiveness in those with panic disorder (PD) with comorbid major depressive disorder (MDD). The aim of the current study was to examine group differences in neural responses to unpredictable and predictable aversiveness in 41 adults with either 1) current PD with comorbid MDD (PD-MDD), 2) current MDD with no lifetime diagnosis of an anxiety disorder (MDD-only), or 3) no lifetime diagnosis of psychopathology. All participants completed a functional magnetic resonance imaging (fMRI) scan while viewing temporally predictable or unpredictable negative or neutral images. |
X Demographics
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 33% |
Student > Ph. D. Student | 5 | 12% |
Student > Master | 5 | 12% |
Professor > Associate Professor | 3 | 7% |
Student > Bachelor | 3 | 7% |
Other | 5 | 12% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
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Psychology | 14 | 33% |
Neuroscience | 5 | 12% |
Agricultural and Biological Sciences | 5 | 12% |
Medicine and Dentistry | 4 | 9% |
Arts and Humanities | 1 | 2% |
Other | 2 | 5% |
Unknown | 12 | 28% |