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Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria

Overview of attention for article published in Malaria Journal, January 2014
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1 tweeter

Citations

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Readers on

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28 Mendeley
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Title
Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria
Published in
Malaria Journal, January 2014
DOI 10.1186/1475-2875-13-105
Pubmed ID
Authors

Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Hiroo Imai, Jun Ohashi

Abstract

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells in microvessels is a remarkable characteristic of severe malaria. The endothelial protein C receptor (EPCR), encoded by the endothelial protein C receptor gene (PROCR), has recently been identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes containing domain cassettes (DCs) 8 and 13. The PROCR rs867186-G allele (serine-to-glycine substitution at position 219 of EPCR; 219Gly) has been shown to be associated with higher levels of plasma soluble EPCR (sEPCR). In this study, the association of PROCR rs867186 with severe malaria is examined in Thai population.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 7%
Malaysia 1 4%
Kenya 1 4%
United Kingdom 1 4%
Canada 1 4%
Belgium 1 4%
Unknown 21 75%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 18%
Researcher 4 14%
Student > Ph. D. Student 4 14%
Student > Bachelor 4 14%
Other 2 7%
Other 7 25%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 46%
Biochemistry, Genetics and Molecular Biology 6 21%
Medicine and Dentistry 4 14%
Immunology and Microbiology 3 11%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2014.
All research outputs
#11,140,367
of 12,524,647 outputs
Outputs from Malaria Journal
#3,377
of 3,658 outputs
Outputs of similar age
#174,179
of 212,904 outputs
Outputs of similar age from Malaria Journal
#9
of 12 outputs
Altmetric has tracked 12,524,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,658 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,904 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.