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Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria

Overview of attention for article published in Malaria Journal, March 2014
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Citations

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Title
Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria
Published in
Malaria Journal, March 2014
DOI 10.1186/1475-2875-13-105
Pubmed ID
Authors

Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Hiroo Imai, Jun Ohashi

Abstract

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells in microvessels is a remarkable characteristic of severe malaria. The endothelial protein C receptor (EPCR), encoded by the endothelial protein C receptor gene (PROCR), has recently been identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes containing domain cassettes (DCs) 8 and 13. The PROCR rs867186-G allele (serine-to-glycine substitution at position 219 of EPCR; 219Gly) has been shown to be associated with higher levels of plasma soluble EPCR (sEPCR). In this study, the association of PROCR rs867186 with severe malaria is examined in Thai population.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
Malaysia 1 2%
Kenya 1 2%
United Kingdom 1 2%
Canada 1 2%
Belgium 1 2%
Unknown 36 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 16%
Student > Ph. D. Student 6 14%
Student > Master 6 14%
Student > Bachelor 5 12%
Other 3 7%
Other 11 26%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 33%
Biochemistry, Genetics and Molecular Biology 10 23%
Medicine and Dentistry 6 14%
Immunology and Microbiology 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 5%
Unknown 7 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2014.
All research outputs
#20,238,443
of 22,765,347 outputs
Outputs from Malaria Journal
#5,314
of 5,554 outputs
Outputs of similar age
#209,368
of 243,465 outputs
Outputs of similar age from Malaria Journal
#86
of 91 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.