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Mendeley readers
| Title |
Tumor necrosis factor-α and muscle wasting: a cellular perspective
|
|---|---|
| Published in |
Respiratory Research, July 2001
|
| DOI | 10.1186/rr67 |
| Pubmed ID | |
| Authors |
Michael B Reid, Yi-Ping Li |
| Abstract |
Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-alpha on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-alpha disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-kappaB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-alpha effects on skeletal muscle and the mechanism of TNF-alpha action. |
Mendeley readers
The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 1% |
| United States | 3 | 1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Poland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 232 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 17% |
| Student > Master | 39 | 16% |
| Researcher | 30 | 12% |
| Student > Bachelor | 29 | 12% |
| Student > Doctoral Student | 11 | 4% |
| Other | 49 | 20% |
| Unknown | 46 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 60 | 24% |
| Agricultural and Biological Sciences | 43 | 18% |
| Biochemistry, Genetics and Molecular Biology | 39 | 16% |
| Sports and Recreations | 14 | 6% |
| Nursing and Health Professions | 9 | 4% |
| Other | 22 | 9% |
| Unknown | 58 | 24% |