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Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential

Overview of attention for article published in Stem Cell Research & Therapy, October 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#26 of 2,415)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
6 news outlets
blogs
1 blog

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
23 Mendeley
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Title
Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential
Published in
Stem Cell Research & Therapy, October 2014
DOI 10.1186/scrt502
Pubmed ID
Authors

Hetal D Marble, Bryan A Sutermaster, Manisha Kanthilal, Vera C Fonseca, Eric M Darling

Abstract

Mesenchymal stem cells have been increasingly used for cell-based therapies. Adipose-derived stem/stromal cells (ASCs) from the stromal vascular fraction (SVF) of fat tissue are a particularly attractive option for cell based therapy given their accessibility and relative abundance. However, their application in both clinical and basic science investigations is complicated by the isolation of differentiable cells within the SVF. Current enrichment strategies, such as monolayer passaging and surface marker-based sorting, can be time-consuming or overly stringent. Ideally, a population of cells with great regenerative capacity could be isolated with high yields so that extensive in vitro manipulation is not necessary. The objective of this study was to determine whether SVF cells sorted based on expression of alkaline phosphatase liver/bone/kidney (ALPL) resulted in populations with increased osteogenic differentiation potential.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
United States 1 4%
Unknown 21 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 35%
Student > Master 4 17%
Student > Ph. D. Student 3 13%
Lecturer 2 9%
Student > Doctoral Student 1 4%
Other 3 13%
Unknown 2 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 26%
Agricultural and Biological Sciences 6 26%
Engineering 3 13%
Medicine and Dentistry 3 13%
Psychology 1 4%
Other 1 4%
Unknown 3 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2014.
All research outputs
#720,390
of 22,765,347 outputs
Outputs from Stem Cell Research & Therapy
#26
of 2,415 outputs
Outputs of similar age
#8,528
of 254,545 outputs
Outputs of similar age from Stem Cell Research & Therapy
#3
of 23 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,415 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,545 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.