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KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells

Overview of attention for article published in Biochemical & Biophysical Research Communications, March 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

wikipedia
33 Wikipedia pages

Citations

dimensions_citation
10 Dimensions

Readers on

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10 Mendeley
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Title
KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells
Published in
Biochemical & Biophysical Research Communications, March 2017
DOI 10.1016/j.bbrc.2017.01.062
Pubmed ID
Authors

Baojin Wang, Airong Shen, Xuan Ouyang, Guannan Zhao, Ziyun Du, Wenying Huo, Tao Zhang, Yinan Wang, Chuanhe Yang, Peixin Dong, Hidemichi Watari, Lawrence M. Pfeffer, Junming Yue

Abstract

KLF4 is a transcriptional factor that can function either as a tumor suppressor or oncogene in cancer based on its cellular context. We recently demonstrated that KLF4 was a tumor suppressor in ovarian cancer cells by inhibiting the epithelial to mesenchymal transition. Here we report that KLF4 expression was downregulated in ovarian cancer tissue compared to normal ovarian tissue, and low KLF4 expression correlated with high risk ovarian carcinoma and poor patient survival. Enforced KLF4 expression by lentiviral transduction sensitized ovarian cancer cells to the effects of the chemotherapy drugs, paclitaxel and cisplatin. Treatment of ovarian cancer cells with APTO-253, a small molecule inducer of KLF4, enhanced the efficacy of both chemotherapy drugs. KLF4 expression mediated by lentiviral vector or induced by APTO-253 resulted in G1 phase arrest in ovarian cancer cells. Our results demonstrate that for the first time that inducing KLF4 expression with APTO-253 is a novel therapeutic strategy for treating ovarian cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 20%
Researcher 2 20%
Lecturer > Senior Lecturer 1 10%
Student > Doctoral Student 1 10%
Student > Master 1 10%
Other 2 20%
Unknown 1 10%
Readers by discipline Count As %
Medicine and Dentistry 3 30%
Immunology and Microbiology 2 20%
Agricultural and Biological Sciences 1 10%
Nursing and Health Professions 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Other 0 0%
Unknown 2 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2017.
All research outputs
#3,490,564
of 12,197,951 outputs
Outputs from Biochemical & Biophysical Research Communications
#4,973
of 20,504 outputs
Outputs of similar age
#99,086
of 285,706 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#16
of 230 outputs
Altmetric has tracked 12,197,951 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,504 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,706 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 230 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.