Title |
Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study
|
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Published in |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, October 2017
|
DOI | 10.1093/gerona/glx204 |
Pubmed ID | |
Authors |
Denise K Houston, Rebecca H Neiberg, Michael E Miller, James O Hill, John M Jakicic, Karen C Johnson, Edward W Gregg, Van S Hubbard, Xavier Pi-Sunyer, W Jack Rejeski, Rena R Wing, John P Bantle, Elizabeth Beale, Robert I Berkowitz, Maria Cassidy-Begay, Jeanne M Clark, Mace Coday, Linda M Delahanty, Gareth Dutton, Caitlin Egan, John P Foreyt, Frank L Greenway, Helen P Hazuda, Andrea Hergenroeder, Edward S Horton, Robert W Jeffery, Steven E Kahn, Anne Kure, William C Knowler, Cora E Lewis, Corby K Martin, Sara Michaels, Maria G Montez, David M Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A Wadden, Karen White, Susan Z Yanovski, Ping Zhang, Stephen B Kritchevsky |
Abstract |
Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Overweight and obese (BMI ≥25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an intensive lifestyle intervention (ILI) designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPBexp), and grip strength approximately 11 years post-randomization and 1.5 years after the intervention was stopped (n=3,783). Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/sec) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71-0.99]). Individuals randomized to ILI also had faster gait speed over 4-m and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007-0.031] m/sec, p=0.002, and 0.023 [0.012-0.034] m/sec, p<0.0001, respectively) and higher SPPBexp scores (0.037 [0.011-0.063], p=0.005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPBexp scores among older vs. younger participants (0.081 [0.038-0.124] vs. 0.013 [-0.021-0.047], p=0.01). An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 191 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 22 | 12% |
Student > Master | 21 | 11% |
Researcher | 13 | 7% |
Student > Ph. D. Student | 10 | 5% |
Student > Postgraduate | 8 | 4% |
Other | 29 | 15% |
Unknown | 88 | 46% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 30 | 16% |
Nursing and Health Professions | 26 | 14% |
Sports and Recreations | 15 | 8% |
Social Sciences | 4 | 2% |
Unspecified | 4 | 2% |
Other | 17 | 9% |
Unknown | 95 | 50% |