Title |
miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
|
---|---|
Published in |
Cell & Bioscience, September 2014
|
DOI | 10.1186/2045-3701-4-56 |
Pubmed ID | |
Authors |
Danielle E Read, Ananya Gupta, Yury Ladilov, Afshin Samali, Sanjeev Gupta |
Abstract |
Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling due to ER stress is associated with the development of myocardial infarction (MI). MicroRNAs (miRNAs) are key regulators of cardiovascular development and deregulation of miRNA expression is involved in the onset of many cardiovascular diseases. However, little is known about the mechanisms regulating the miRNA expression in the cardiovascular system during disease development and progression. Here we performed genome-wide miRNA expression profiling in rat cardiomyoblasts to identify the miRNAs deregulated during UPR, a crucial component of ischemia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 30% |
Student > Ph. D. Student | 6 | 18% |
Student > Bachelor | 2 | 6% |
Student > Master | 2 | 6% |
Student > Doctoral Student | 1 | 3% |
Other | 4 | 12% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 24% |
Medicine and Dentistry | 6 | 18% |
Agricultural and Biological Sciences | 4 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 4 | 12% |
Unknown | 9 | 27% |