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CORK Study in Cystic Fibrosis

Overview of attention for article published in CHEST, February 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
6 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
55 Dimensions

Readers on

mendeley
66 Mendeley
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Title
CORK Study in Cystic Fibrosis
Published in
CHEST, February 2018
DOI 10.1016/j.chest.2017.10.005
Pubmed ID
Authors

Nicola J. Ronan, Gisli G. Einarsson, Maria Twomey, Denver Mooney, David Mullane, Muireann NiChroinin, Grace O’Callaghan, Fergus Shanahan, Desmond M. Murphy, Owen J. O’Connor, Cathy A. Shortt, Michael M. Tunney, Joseph A. Eustace, Michael M. Maher, J. Stuart Elborn, Barry J. Plant

Abstract

Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at Cork CF Centre is 23%. This study assessed the impact of CFTR modulation on multiple modalities of patient assessment. Thirty three patients with the G551D mutation were assessed at baseline and prospectively three monthly for one year post initiation of ivacaftor. Change in ultra-low dose chest CT, blood inflammatory mediators, and sputum microbiome were assessed. Significant improvements in FEV1, BMI and sweat chloride were observed post-ivacaftor. Improvement in ultra-low dose CT scores were observed after treatment with significant mean reductions in total Bhalla score (p< 0(.)01), peri-bronchial thickening (p = 0(.)035) and extent of mucus plugging (p< 0(.)001). Reductions in circulating inflammatory markers, including IL-1β, IL-6, and IL-8 were demonstrated. There was a 30% reduction in the relative abundance of Pseudomonas spp. and an increase in the relative abundance of bacteria associated with more stable community structures. Post-treatment community richness increased significantly (p = 0.03). Early and sustained improvements on ultra-low-dose CT scores suggest it may be a useful method of evaluating treatment response. It was paralleled improvement in symptoms, circulating inflammatory markers, and changes in the lung microbiota.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 21%
Student > Bachelor 8 12%
Student > Ph. D. Student 7 11%
Student > Master 7 11%
Other 5 8%
Other 9 14%
Unknown 16 24%
Readers by discipline Count As %
Medicine and Dentistry 18 27%
Biochemistry, Genetics and Molecular Biology 5 8%
Immunology and Microbiology 4 6%
Nursing and Health Professions 3 5%
Agricultural and Biological Sciences 3 5%
Other 9 14%
Unknown 24 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2019.
All research outputs
#4,739,297
of 15,606,530 outputs
Outputs from CHEST
#3,774
of 9,719 outputs
Outputs of similar age
#113,837
of 322,300 outputs
Outputs of similar age from CHEST
#112
of 199 outputs
Altmetric has tracked 15,606,530 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 9,719 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,300 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 199 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.