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Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Overview of attention for article published in Arthritis Research & Therapy, October 2014
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Title
Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies
Published in
Arthritis Research & Therapy, October 2014
DOI 10.1186/s13075-014-0454-8
Pubmed ID
Authors

Olga Kryštůfková, Sevim Barbasso Helmers, Paulius Venalis, Vivianne Malmström, Eva Lindroos, Jiří Vencovský, Ingrid E Lundberg

Abstract

IntroductionAnti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis, but the mechanisms for their production are not known. Survival of autoantibody producing cells is dependent on B cell activating factor of the TNF family (BAFF). BAFF levels are elevated in serum of anti-Jo-1+ myositis patients and are influenced by type I interferon (IFN). IFN producing cells and BAFF mRNA expression are present in myositis muscle. We investigated expression of the receptors for BAFF in muscle tissue in relation to anti-Jo-1 and anti-Ro52/anti-Ro60 autoantibodies and type I IFN markers.MethodsMuscle biopsies from 23 myositis patients, selected by autoantibody profile and seven healthy controls were investigated for expression of BAFF receptor (BAFF-R), B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Nineteen of these were assessed for plasma (CD138) and B cell (CD19) markers. Positively stained cells per area were compared with expression of plasmacytoid dendritic cell (pDC) marker blood dendritic cell antigen-2 (BDCA-2) and IFN¿/ß-inducible myxovirus resistance-1 protein (MX-1).ResultsBAFF-R, BCMA and TACI were expressed in five, seven and seven patients respectively and more frequently in anti-Jo-1+ and/or anti-Ro52/anti-Ro60+ patients compared to patients without these autoantibodies and controls (P¿=¿BAFF-R: 0.007, BCMA: 0.03 and TACI: 0.07). A local association of receptors with B and plasma cells in serial sections was confirmed by confocal microscopy. The numbers of CD138+ and BCMA+ cells correlated (rs¿=¿0.79; P¿=¿0.001).Expression of BDCA-2 correlated with numbers of CD138+ and marginally with BCMA+ cells (rs¿=¿0.54 and 0.42; P¿=¿0.04 and 0.06). There was a borderline correlation between the number of TACI+ cells and MX-1+ areas (rs¿=¿0.38; P¿=¿0.08).ConclusionsThe expression pattern of BAFF receptors on B and plasma cells in muscle suggests a local role for BAFF in autoantibody production in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. BAFF production could be influenced by type I IFN produced by pDCs. Thus B cell related molecular pathways may have a role in the pathogenesis in this subset of myositis patients.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 10%
Unknown 18 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Other 4 20%
Researcher 3 15%
Unspecified 2 10%
Student > Doctoral Student 2 10%
Other 4 20%
Readers by discipline Count As %
Medicine and Dentistry 11 55%
Unspecified 2 10%
Agricultural and Biological Sciences 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Immunology and Microbiology 1 5%
Other 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2014.
All research outputs
#7,813,292
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#1,413
of 1,983 outputs
Outputs of similar age
#109,509
of 215,322 outputs
Outputs of similar age from Arthritis Research & Therapy
#23
of 36 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.