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Attention Score in Context
| Title |
Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies
|
|---|---|
| Published in |
Arthritis Research & Therapy, October 2014
|
| DOI | 10.1186/s13075-014-0454-8 |
| Pubmed ID | |
| Authors |
Olga Kryštůfková, Sevim Barbasso Helmers, Paulius Venalis, Vivianne Malmström, Eva Lindroos, Jiří Vencovský, Ingrid E Lundberg |
| Abstract |
IntroductionAnti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis, but the mechanisms for their production are not known. Survival of autoantibody producing cells is dependent on B cell activating factor of the TNF family (BAFF). BAFF levels are elevated in serum of anti-Jo-1+ myositis patients and are influenced by type I interferon (IFN). IFN producing cells and BAFF mRNA expression are present in myositis muscle. We investigated expression of the receptors for BAFF in muscle tissue in relation to anti-Jo-1 and anti-Ro52/anti-Ro60 autoantibodies and type I IFN markers.MethodsMuscle biopsies from 23 myositis patients, selected by autoantibody profile and seven healthy controls were investigated for expression of BAFF receptor (BAFF-R), B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Nineteen of these were assessed for plasma (CD138) and B cell (CD19) markers. Positively stained cells per area were compared with expression of plasmacytoid dendritic cell (pDC) marker blood dendritic cell antigen-2 (BDCA-2) and IFN¿/ß-inducible myxovirus resistance-1 protein (MX-1).ResultsBAFF-R, BCMA and TACI were expressed in five, seven and seven patients respectively and more frequently in anti-Jo-1+ and/or anti-Ro52/anti-Ro60+ patients compared to patients without these autoantibodies and controls (P¿=¿BAFF-R: 0.007, BCMA: 0.03 and TACI: 0.07). A local association of receptors with B and plasma cells in serial sections was confirmed by confocal microscopy. The numbers of CD138+ and BCMA+ cells correlated (rs¿=¿0.79; P¿=¿0.001).Expression of BDCA-2 correlated with numbers of CD138+ and marginally with BCMA+ cells (rs¿=¿0.54 and 0.42; P¿=¿0.04 and 0.06). There was a borderline correlation between the number of TACI+ cells and MX-1+ areas (rs¿=¿0.38; P¿=¿0.08).ConclusionsThe expression pattern of BAFF receptors on B and plasma cells in muscle suggests a local role for BAFF in autoantibody production in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. BAFF production could be influenced by type I IFN produced by pDCs. Thus B cell related molecular pathways may have a role in the pathogenesis in this subset of myositis patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 6% |
| Unknown | 30 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Ph. D. Student | 5 | 16% |
| Other | 4 | 13% |
| Student > Doctoral Student | 4 | 13% |
| Student > Postgraduate | 2 | 6% |
| Other | 5 | 16% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 41% |
| Nursing and Health Professions | 3 | 9% |
| Immunology and Microbiology | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 5 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2014.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#2,536
of 3,381 outputs
Outputs of similar age
#161,137
of 268,350 outputs
Outputs of similar age from Arthritis Research & Therapy
#34
of 54 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.