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Comparison of long‐term outcomes of 50 and 100 mg rt‐PA in the management of acute pulmonary thromboembolism

Overview of attention for article published in Clinical Respiratory Journal, November 2017
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Title
Comparison of long‐term outcomes of 50 and 100 mg rt‐PA in the management of acute pulmonary thromboembolism
Published in
Clinical Respiratory Journal, November 2017
DOI 10.1111/crj.12721
Pubmed ID
Authors

Elif Yilmazel Ucar, Omer Araz, Bugra Kerget, Nafiye Yilmaz, Metin Akgun, Leyla Saglam

Abstract

Pulmonary thromboembolism (PTE) is a life-threatening disease. In this study, we aimed to evaluate long-term outcomes of the use of 50 mg recombinant tissue-type plasminogen activator (rt-PA) in the management of PTE in terms of relapse, pulmonary hypertension (PH), mortality and hemorrhage, and to compare with the use of 100 mg rt-PA. The study was designed as a retrospective cohort. Patients who were diagnosed as acute PTE and received either 50 mg or 100 mg rt-PA in a tertiary care hospital between 2010 and 2015 were included in the study. Rates of relapse, PH, mortality (in-hospital and long-term) and hemorrhage (major and minor) were calculated for each treatment group. A total 117 patients, 73 female and 44 male, were evaluated. Eighty-three patients were administered 100 mg rt-PA and 34 were administered 50 mg rt-PA. Mean age was lower in the 100 mg group compared to the 50 mg group (61±15 versus 69±14 years). There was a significant decrease in PH in each group at 3 months follow-up (p<0.001). Although statistically nonsignificant, the relapse rate was lower in the 50 mg rt-PA group, but the 5-year mortality rate was higher in 50 mg rt-PA group (35.2% versus 27.7%, p=0.50). Mortality was associated with older age and presence of malignancy. Our results suggest that both doses of rt-PA have similar efficacy. The high mortality rate in the 50 mg group may have resulted from patient selection. This article is protected by copyright. All rights reserved.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Professor 3 30%
Student > Postgraduate 2 20%
Professor > Associate Professor 1 10%
Lecturer 1 10%
Student > Master 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Medicine and Dentistry 5 50%
Engineering 1 10%
Unknown 4 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2017.
All research outputs
#14,215,589
of 16,116,890 outputs
Outputs from Clinical Respiratory Journal
#386
of 548 outputs
Outputs of similar age
#275,963
of 324,270 outputs
Outputs of similar age from Clinical Respiratory Journal
#19
of 32 outputs
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