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Effect of exercise training on Ca2+ release units of left ventricular myocytes of spontaneously hypertensive rats

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, August 2014
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Title
Effect of exercise training on Ca2+ release units of left ventricular myocytes of spontaneously hypertensive rats
Published in
Brazilian Journal of Medical and Biological Research, August 2014
DOI 10.1590/1414-431x20144063
Pubmed ID
Authors

M.A. Carneiro-Júnior, J.F. Quintão-Júnior, L.R. Drummond, V.N. Lavorato, F.R. Drummond, M.A. Amadeu, E.M. Oliveira, L.B. Felix, J.S. Cruz, J.G. Mill, A.J. Natali, T.N. Prímola-Gomes

Abstract

In cardiomyocytes, calcium (Ca2+) release units comprise clusters of intracellular Ca2+ release channels located on the sarcoplasmic reticulum, and hypertension is well established as a cause of defects in calcium release unit function. Our objective was to determine whether endurance exercise training could attenuate the deleterious effects of hypertension on calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats. Male Wistar and spontaneously hypertensive rats (4 months of age) were divided into 4 groups: normotensive (NC) and hypertensive control (HC), and normotensive (NT) and hypertensive trained (HT) animals (7 rats per group). NC and HC rats were submitted to a low-intensity treadmill running protocol (5 days/week, 1 h/day, 0% grade, and 50-60% of maximal running speed) for 8 weeks. Gene expression of the ryanodine receptor type 2 (RyR2) and FK506 binding protein (FKBP12.6) increased (270%) and decreased (88%), respectively, in HC compared to NC rats. Endurance exercise training reversed these changes by reducing RyR2 (230%) and normalizing FKBP12.6 gene expression (112%). Hypertension also increased the frequency of Ca2+ sparks (HC=7.61±0.26 vs NC=4.79±0.19 per 100 µm/s) and decreased its amplitude (HC=0.260±0.08 vs NC=0.324±0.10 ΔF/F0), full width at half-maximum amplitude (HC=1.05±0.08 vs NC=1.26±0.01 µm), total duration (HC=11.51±0.12 vs NC=14.97±0.24 ms), time to peak (HC=4.84±0.06 vs NC=6.31±0.14 ms), and time constant of decay (HC=8.68±0.12 vs NC=10.21±0.22 ms). These changes were partially reversed in HT rats (frequency of Ca2+ sparks=6.26±0.19 µm/s, amplitude=0.282±0.10 ΔF/F0, full width at half-maximum amplitude=1.14±0.01 µm, total duration=13.34±0.17 ms, time to peak=5.43±0.08 ms, and time constant of decay=9.43±0.15 ms). Endurance exercise training attenuated the deleterious effects of hypertension on calcium release units of left ventricular myocytes.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 15%
Professor 6 13%
Student > Bachelor 6 13%
Student > Ph. D. Student 4 9%
Researcher 2 4%
Other 7 15%
Unknown 15 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 17%
Agricultural and Biological Sciences 7 15%
Medicine and Dentistry 4 9%
Sports and Recreations 3 6%
Nursing and Health Professions 1 2%
Other 4 9%
Unknown 20 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2014.
All research outputs
#18,380,628
of 22,766,595 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#835
of 1,168 outputs
Outputs of similar age
#168,261
of 236,204 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#15
of 19 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,168 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,204 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.