Title |
Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer
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Published in |
Clinical Epigenetics, October 2014
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DOI | 10.1186/1868-7083-6-20 |
Pubmed ID | |
Authors |
Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Arunima Shilpi, Sabnam Parbin, Sandip Kumar Rath, Nibedita Pradhan, Madhumita Rakshit, Samir Kumar Patra |
Abstract |
DNA methylation mediates gene silencing primarily by inducing repressive chromatin architecture via a common theme of interaction involving methyl-CpG binding (MBD) proteins, histone modifying enzymes and chromatin remodelling complexes. Hence, targeted inhibition of MBD protein function is now considered a potential therapeutic alternative for thwarting DNA hypermethylation prompted neoplastic progress. We have analyzed the gene and protein expression level of the principal factors responsible for gene silencing, that is, DNMT and MBD proteins in MCF-7 and MDA-MB-231 breast cancer cell lines after treatment with various epigenetic drugs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Belgium | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 20% |
Student > Ph. D. Student | 10 | 15% |
Student > Bachelor | 7 | 11% |
Researcher | 7 | 11% |
Student > Doctoral Student | 4 | 6% |
Other | 11 | 17% |
Unknown | 14 | 21% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 26% |
Biochemistry, Genetics and Molecular Biology | 16 | 24% |
Medicine and Dentistry | 8 | 12% |
Immunology and Microbiology | 3 | 5% |
Veterinary Science and Veterinary Medicine | 2 | 3% |
Other | 4 | 6% |
Unknown | 16 | 24% |