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Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer

Overview of attention for article published in Clinical Epigenetics, October 2014
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Title
Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer
Published in
Clinical Epigenetics, October 2014
DOI 10.1186/1868-7083-6-20
Pubmed ID
Authors

Swayamsiddha Kar, Dipta Sengupta, Moonmoon Deb, Arunima Shilpi, Sabnam Parbin, Sandip Kumar Rath, Nibedita Pradhan, Madhumita Rakshit, Samir Kumar Patra

Abstract

DNA methylation mediates gene silencing primarily by inducing repressive chromatin architecture via a common theme of interaction involving methyl-CpG binding (MBD) proteins, histone modifying enzymes and chromatin remodelling complexes. Hence, targeted inhibition of MBD protein function is now considered a potential therapeutic alternative for thwarting DNA hypermethylation prompted neoplastic progress. We have analyzed the gene and protein expression level of the principal factors responsible for gene silencing, that is, DNMT and MBD proteins in MCF-7 and MDA-MB-231 breast cancer cell lines after treatment with various epigenetic drugs.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Student > Ph. D. Student 10 15%
Student > Bachelor 7 11%
Researcher 7 11%
Student > Doctoral Student 4 6%
Other 11 17%
Unknown 14 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 26%
Biochemistry, Genetics and Molecular Biology 16 24%
Medicine and Dentistry 8 12%
Immunology and Microbiology 3 5%
Veterinary Science and Veterinary Medicine 2 3%
Other 4 6%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2014.
All research outputs
#18,380,628
of 22,766,595 outputs
Outputs from Clinical Epigenetics
#989
of 1,243 outputs
Outputs of similar age
#182,716
of 255,754 outputs
Outputs of similar age from Clinical Epigenetics
#12
of 12 outputs
Altmetric has tracked 22,766,595 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,754 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.