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X Demographics
Mendeley readers
Attention Score in Context
| Title |
DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress
|
|---|---|
| Published in |
Nature Communications, October 2017
|
| DOI | 10.1038/s41467-017-01195-y |
| Pubmed ID | |
| Authors |
Bing Yao, Ying Cheng, Zhiqin Wang, Yujing Li, Li Chen, Luoxiu Huang, Wenxin Zhang, Dahua Chen, Hao Wu, Beisha Tang, Peng Jin |
| Abstract |
Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain unclear. Here we demonstrate 6mA dynamics in the mouse brain in response to environmental stress. We find that overall 6mA levels are significantly elevated upon stress. Genome-wide 6mA and transcriptome profiling reveal an inverse association between 6mA dynamic changes and a set of upregulated neuronal genes or downregulated LINE transposon expression. Genes bearing stress-induced 6mA changes significantly overlap with loci associated with neuropsychiatric disorders. These results suggest an epigenetic role for 6mA in the mammalian brain as well as its potential involvement in neuropsychiatric disorders. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 28% |
| Saudi Arabia | 3 | 9% |
| France | 2 | 6% |
| Japan | 1 | 3% |
| Ecuador | 1 | 3% |
| China | 1 | 3% |
| United Kingdom | 1 | 3% |
| Australia | 1 | 3% |
| Unknown | 13 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 69% |
| Scientists | 8 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 199 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 22% |
| Researcher | 29 | 15% |
| Student > Bachelor | 22 | 11% |
| Student > Master | 20 | 10% |
| Student > Doctoral Student | 11 | 6% |
| Other | 26 | 13% |
| Unknown | 48 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 59 | 30% |
| Agricultural and Biological Sciences | 36 | 18% |
| Neuroscience | 11 | 6% |
| Chemistry | 7 | 4% |
| Medicine and Dentistry | 6 | 3% |
| Other | 22 | 11% |
| Unknown | 58 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 97. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2023.
All research outputs
#417,439
of 24,716,872 outputs
Outputs from Nature Communications
#6,919
of 53,628 outputs
Outputs of similar age
#9,008
of 333,248 outputs
Outputs of similar age from Nature Communications
#200
of 1,451 outputs
Altmetric has tracked 24,716,872 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 53,628 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,451 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.