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Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor- 1 in airway fibroblasts in asthma

Overview of attention for article published in European Respiratory Journal, May 2013
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1 tweeter
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Citations

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54 Dimensions

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38 Mendeley
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Title
Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor- 1 in airway fibroblasts in asthma
Published in
European Respiratory Journal, May 2013
DOI 10.1183/09031936.00068712
Pubmed ID
Authors

R. Firszt, D. Francisco, T. D. Church, J. M. Thomas, J. L. Ingram, M. Kraft

Abstract

Airway remodelling is a feature of asthma that contributes to loss of lung function. One of the central components of airway remodelling is subepithelial fibrosis. Interleukin (IL)-13 is a key T-helper 2 cytokine and is believed to be the central mediator of allergic asthma including remodelling, but the mechanism driving the latter has not been elucidated in human asthma. We hypothesised that IL-13 stimulates collagen type-1 production by the airway fibroblast in a matrix metalloproteinase (MMP)- and transforming growth factor (TGF)-β1-dependent manner in human asthma as compared to healthy controls. Fibroblasts were cultured from endobronchial biopsies in 14 subjects with mild asthma and 13 normal controls that underwent bronchoscopy. Airway fibroblasts were treated with various mediators including IL-13 and specific MMP-inhibitors. IL-13 significantly stimulated collagen type-1 production in asthma compared to normal controls. Inhibitors of MMP-2 significantly attenuated collagen production in asthma but had no effect in normal controls. IL-13 significantly increased total and active forms of TGF-β1, and this activation was blocked using an MMP-2 inhibitor. IL-13 activated endogenous MMP-2 in asthma patients as compared to normal controls. In an ex vivo model, IL-13 potentiates airway remodelling through a mechanism involving TGF-β1 and MMP-2. These effects provide insights into the mechanism involved in IL-13-directed airway remodelling in asthma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 21%
Student > Ph. D. Student 7 18%
Researcher 6 16%
Student > Bachelor 4 11%
Other 2 5%
Other 6 16%
Unknown 5 13%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Immunology and Microbiology 7 18%
Biochemistry, Genetics and Molecular Biology 4 11%
Agricultural and Biological Sciences 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 11%
Unknown 8 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2015.
All research outputs
#7,415,010
of 12,342,987 outputs
Outputs from European Respiratory Journal
#4,127
of 5,553 outputs
Outputs of similar age
#105,830
of 225,733 outputs
Outputs of similar age from European Respiratory Journal
#68
of 90 outputs
Altmetric has tracked 12,342,987 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,553 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,733 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.