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Lewis Rat Model of Experimental Autoimmune Encephalomyelitis

Overview of attention for article published in Current protocols in neuroscience, February 2018
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Mentioned by

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3 tweeters

Citations

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4 Dimensions

Readers on

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11 Mendeley
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Title
Lewis Rat Model of Experimental Autoimmune Encephalomyelitis
Published in
Current protocols in neuroscience, February 2018
DOI 10.1002/cpns.36
Pubmed ID
Authors

Kalliopi Pitarokoili, Bjoern Ambrosius, Ralf Gold

Abstract

In this unit, we describe in detail the most common methods used to break immunological tolerance for central myelin antigens and induce experimental autoimmune encephalomyelitis (EAE) in Lewis rats as an animal model of multiple sclerosis. The resulting disease course ranges from an acute monophasic disease to a chronic relapsing or chronic progressive course, which strongly resembles the human disease. These models enable the study of cellular and humoral autoimmunity against major antigenic epitopes of the myelin basic protein, myelin oligodendrocyte glycoprotein, or proteolipid protein. We provide an overview of common immunization protocols for induction of active and passive EAE, assessment and analysis of clinical score, preparation and purification of myelin basic protein, and derivation of neuroantigen-specific rat T cell lines. Finally, we describe the major clinical characteristics of these models. © 2017 by John Wiley & Sons, Inc.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 18%
Researcher 2 18%
Student > Master 1 9%
Student > Bachelor 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Unknown 2 18%
Readers by discipline Count As %
Neuroscience 5 45%
Biochemistry, Genetics and Molecular Biology 3 27%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Engineering 1 9%
Unknown 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2017.
All research outputs
#8,382,322
of 13,921,888 outputs
Outputs from Current protocols in neuroscience
#75
of 116 outputs
Outputs of similar age
#170,862
of 317,340 outputs
Outputs of similar age from Current protocols in neuroscience
#4
of 5 outputs
Altmetric has tracked 13,921,888 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 116 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,340 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.