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Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

Overview of attention for article published in The Journal of Immunology, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
1 tweeter
patent
4 patents

Citations

dimensions_citation
79 Dimensions

Readers on

mendeley
99 Mendeley
citeulike
1 CiteULike
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Title
Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation
Published in
The Journal of Immunology, October 2014
DOI 10.4049/jimmunol.1402051
Pubmed ID
Authors

Qifan Zhu, Si Ming Man, Prajwal Gurung, Zhiping Liu, Peter Vogel, Mohamed Lamkanfi, Thirumala-Devi Kanneganti

Abstract

Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and autoimmune diseases, its physiological role in cancer is unknown. In this study, we show that STING-deficient mice are highly susceptible to colitis-associated colorectal cancer. Colons of STING-deficient mice exhibit significant intestinal damage and overt proliferation during early stages of tumorigenesis. Moreover, STING-deficient mice fail to restrict activation of the NF-κB- and STAT3-signaling pathways, which leads to increased levels of the proinflammatory cytokines IL-6 and KC. Therefore, our results identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
France 1 1%
Austria 1 1%
Unknown 96 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 31%
Student > Ph. D. Student 27 27%
Student > Doctoral Student 7 7%
Student > Bachelor 5 5%
Other 4 4%
Other 10 10%
Unknown 15 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 24%
Medicine and Dentistry 19 19%
Biochemistry, Genetics and Molecular Biology 14 14%
Immunology and Microbiology 11 11%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 7 7%
Unknown 19 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2020.
All research outputs
#3,311,340
of 16,948,032 outputs
Outputs from The Journal of Immunology
#2,492
of 17,465 outputs
Outputs of similar age
#47,641
of 237,542 outputs
Outputs of similar age from The Journal of Immunology
#25
of 240 outputs
Altmetric has tracked 16,948,032 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,465 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 240 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.