Title |
MRC ORACLE Children Study. Long term outcomes following prescription of antibiotics to pregnant women with either spontaneous preterm labour or preterm rupture of the membranes
|
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Published in |
BMC Pregnancy and Childbirth, April 2008
|
DOI | 10.1186/1471-2393-8-14 |
Pubmed ID | |
Authors |
Sara Kenyon, Peter Brocklehurst, David Jones, Neil Marlow, Alison Salt, David Taylor |
Abstract |
The Medical Research Council (MRC) ORACLE trial evaluated the use of co-amoxiclav 375 mg and/or erythromycin 250 mg in women presenting with preterm rupture of membranes (PROM) ORACLE I or in spontaneous preterm labour (SPL) ORACLE II using a factorial design. The results showed that for women with a singleton baby with PROM the prescription of erythromycin is associated with improvements in short term neonatal outcomes, although co-amoxiclav is associated with prolongation of pregnancy, a significantly higher rate of neonatal necrotising enterocolitis was found in these babies. Prescription of erythromycin is now established practice for women with PROM. For women with SPL antibiotics demonstrated no improvements in short term neonatal outcomes and are not recommended treatment. There is evidence that both these conditions are associated with subclinical infection so perinatal antibiotic administration may reduce the risk of later disabilities, including cerebral palsy, although the risk may be increased through exposure to inflammatory cytokines, so assessment of longer term functional and educational outcomes is appropriate. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | <1% |
Tanzania, United Republic of | 1 | <1% |
Ireland | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 139 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 24 | 17% |
Student > Master | 22 | 15% |
Researcher | 17 | 12% |
Student > Doctoral Student | 12 | 8% |
Student > Bachelor | 12 | 8% |
Other | 33 | 23% |
Unknown | 24 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 64 | 44% |
Nursing and Health Professions | 16 | 11% |
Social Sciences | 8 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Psychology | 5 | 3% |
Other | 13 | 9% |
Unknown | 31 | 22% |