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Oral insulin improves metabolic parameters in high fat diet fed rats

Overview of attention for article published in Anais da Academia Brasileira de Ciências, September 2017
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Title
Oral insulin improves metabolic parameters in high fat diet fed rats
Published in
Anais da Academia Brasileira de Ciências, September 2017
DOI 10.1590/0001-3765201720170040
Pubmed ID
Authors

LEANDRO C. LIPINSKI, LOUISE B. KMETIUK, PAULO C.F. MATHIAS, ANANDA MALTA, GIOVANI M. FAVERO, TATIANE A. RIBEIRO, ALCEU TOLEDO, MARIO R. MONTEMOR NETTO, MARCOS R.S. RODRIGUES

Abstract

The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS). Weight and food consumption were weekly obtained. After eight weeks, fasting blood samples were collected for laboratorial analysis. After euthanasia gut samples were isolated. Rat oral insulin treatment decreased body weight gain (p<0,001), fasting glucose and triglycerides serum levels (p<0,05) an increased intestinal weight of distal ileum (P<0,05). Animal submitted to high fat diet presented higher levels of HOMA-IR although significant difference to CT was not achieved. HOMA-beta were significantly higher (p<0.05) in HFD+INS. Visceral fat was 10% lower in HFD+INS but the difference was not significant. In non-diabetic obese rats, oral insulin improves metabolic malfunction associated to rescue of beta-cell activity.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 20%
Professor 3 12%
Student > Bachelor 3 12%
Researcher 3 12%
Student > Master 2 8%
Other 3 12%
Unknown 6 24%
Readers by discipline Count As %
Medicine and Dentistry 4 16%
Biochemistry, Genetics and Molecular Biology 3 12%
Nursing and Health Professions 2 8%
Arts and Humanities 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 5 20%
Unknown 9 36%