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Therapeutic Oligonucleotides

Overview of attention for book
Cover of 'Therapeutic Oligonucleotides'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Therapeutic oligonucleotides.
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    Chapter 2 Therapeutic Oligonucleotides
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    Chapter 3 2′-O,4′-C-Methyleneoxymethylene Bridged Nucleic Acids (2′,4′-BNACOC)
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    Chapter 4 A Non-covalent Peptide-Based Strategy for Ex Vivo and In Vivo Oligonucleotide Delivery.
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    Chapter 5 Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides.
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    Chapter 6 A nanoparticle for tumor targeted delivery of oligomers.
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    Chapter 7 Light-Directed Delivery of Nucleic Acids
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    Chapter 8 Antibody Targeted siRNA Delivery.
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    Chapter 9 Aptamer-drug conjugation for targeted tumor cell therapy.
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    Chapter 10 Five-Step Process for Screening Antisense Compounds for Efficacy: Gene Target IL-12Rb2
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    Chapter 11 Diverse Small Non-coding RNAs in RNA Interference Pathways.
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    Chapter 12 Quantification of siRNAs In Vitro and In Vivo.
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    Chapter 13 Optimization of Transfection Conditions and Analysis of siRNA Potency Using Real-time PCR.
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    Chapter 14 siRNA Knockdown of Gene Expression in Endothelial Cells.
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    Chapter 15 Using RNA Interference in Schistosoma mansoni
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    Chapter 16 Performing the Labeled microRNA Pull-Down (LAMP) Assay System: An Experimental Approach for High-Throughput Identification of microRNA-Target mRNAs.
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    Chapter 17 Synthesis, Purification, and Characterization of Oligoribonucleotides that Act as Agonists of TLR7 and/or TLR8
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    Chapter 18 Synthesis, Purification, and Characterization of Immune-Modulatory Oligodeoxynucleotides that Act as Agonists of Toll-Like Receptor 9
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    Chapter 19 Surface Plasmon Resonance Investigation of RNA Aptamer–RNA Ligand Interactions
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    Chapter 20 Practical Considerations for Analyzing Antigene RNAs (agRNAs): RNA Immunoprecipitation of Argonaute Protein
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    Chapter 21 Inhibition of Human Papillomavirus Expression Using DNAzymes
Attention for Chapter 6: A nanoparticle for tumor targeted delivery of oligomers.
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Citations

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Chapter title
A nanoparticle for tumor targeted delivery of oligomers.
Chapter number 6
Book title
Therapeutic Oligonucleotides
Published in
Methods in molecular biology, January 2011
DOI 10.1007/978-1-61779-188-8_6
Pubmed ID
Book ISBNs
978-1-61779-187-1, 978-1-61779-188-8
Authors

Liu X, Wang Y, Hnatowich DJ, Xinrong Liu, Yi Wang, Donald J. Hnatowich

Abstract

The tissue-specific delivery nanoparticle consists of an antisense oligomer, a cell-penetrating peptide, and an antitumor antibody, each biotinylated and each linked via streptavidin. Within the nanoparticle, the antibody provides specific targeted delivery and binding to the target cells, the peptide improves cell membrane transport, and the antisense oligomer, through its mRNA-binding ability, provides specific retention of the radioactivity in the target cell nucleus. The use of streptavidin as linker eliminates the need for covalent conjugation without appearing to interfere with the in vitro and in vivo properties of each component. The delivery nanoparticle is under development to improve tumor targeting with unlabeled siRNAs as well as radiolabeled antisense oligomers in a variety of tumor types. The anti-HER2 Trastuzumab (Herceptin) antibody, the tat peptide, and a radiolabeled antisense oligomer against the RIα mRNA have been used in this report as an example.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 22%
Student > Bachelor 2 22%
Student > Ph. D. Student 2 22%
Professor 1 11%
Student > Master 1 11%
Other 1 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 33%
Medicine and Dentistry 2 22%
Physics and Astronomy 1 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Unknown 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2011.
All research outputs
#9,077,966
of 11,339,688 outputs
Outputs from Methods in molecular biology
#3,867
of 7,665 outputs
Outputs of similar age
#66,275
of 84,379 outputs
Outputs of similar age from Methods in molecular biology
#6
of 8 outputs
Altmetric has tracked 11,339,688 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,665 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.