Title |
Metabolic programming of adipose tissue structure and function in male rat offspring by prenatal undernutrition
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Published in |
Nutrition & Metabolism, October 2014
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DOI | 10.1186/1743-7075-11-50 |
Pubmed ID | |
Authors |
Nichola Thompson, Korinna Huber, Mirijam Bedürftig, Kathrin Hansen, Jennifer Miles-Chan, Bernhard H Breier |
Abstract |
A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous rat studies have shown that maternal undernutrition during pregnancy led to insulin hyper-secretion and obesity in offspring, but not to systemic insulin resistance. Increased muscle and liver glycogen stores indicated that glucose is taken up efficiently, reflecting an active physiological function of these energy storage tissues. It is increasingly recognised that adipose tissue plays a central role in the regulation of metabolism and pathophysiology of obesity development. The present study investigated the cell size and endocrine responsiveness of subcutaneous and visceral adipose tissue from prenatally undernourished rats. We aimed to identify whether these adipose tissue depots contribute to the altered energy metabolism observed in these offspring. |
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