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Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Title
Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20176087
Pubmed ID
Authors

J.C. Shen, Y.C. Zhang, M.F. Zhao

Abstract

Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 56%
Professor > Associate Professor 1 11%
Student > Bachelor 1 11%
Other 1 11%
Student > Master 1 11%
Other 0 0%
Readers by discipline Count As %
Unspecified 5 56%
Biochemistry, Genetics and Molecular Biology 1 11%
Business, Management and Accounting 1 11%
Psychology 1 11%
Medicine and Dentistry 1 11%
Other 0 0%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2017.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Brazilian Journal of Medical and Biological Research
#743
of 1,254 outputs
Outputs of similar age
#267,895
of 421,709 outputs
Outputs of similar age from Brazilian Journal of Medical and Biological Research
#20
of 63 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,254 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,709 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.