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Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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Title
Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20176087
Pubmed ID
Authors

J.C. Shen, Y.C. Zhang, M.F. Zhao

Abstract

Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.

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Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 50%
Other 1 50%
Readers by discipline Count As %
Business, Management and Accounting 1 50%
Psychology 1 50%