Title |
Control of HIV infection by IFN-α: implications for latency and a cure
|
---|---|
Published in |
Cellular and Molecular Life Sciences, October 2017
|
DOI | 10.1007/s00018-017-2652-4 |
Pubmed ID | |
Authors |
Nollaig M. Bourke, Silvia Napoletano, Ciaran Bannan, Suaad Ahmed, Colm Bergin, Áine McKnight, Nigel J. Stevenson |
Abstract |
Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active anti-retroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α. In addition, we discuss the relevance of type I IFN treatment in the context of HIV latency reversal, novel therapeutic intervention strategies and the potential for full HIV clearance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 5 | 71% |
India | 1 | 14% |
United Kingdom | 1 | 14% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 18% |
Student > Master | 10 | 18% |
Student > Bachelor | 10 | 18% |
Researcher | 8 | 14% |
Student > Doctoral Student | 2 | 4% |
Other | 1 | 2% |
Unknown | 15 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 21% |
Agricultural and Biological Sciences | 8 | 14% |
Immunology and Microbiology | 8 | 14% |
Medicine and Dentistry | 3 | 5% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 9% |
Unknown | 18 | 32% |